Small Molecules acting on Myofilaments as Treatments for Heart and Skeletal Muscle Diseases

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Small Molecules acting on Myofilaments as Treatments for Heart and Skeletal Muscle Diseases

Hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) are probably the most prevalent types of the continual and progressive pathological situation often called cardiomyopathy. These illnesses have totally different aetiologies; nonetheless, they share the characteristic of haemodynamic abnormalities, which is principally attributable to dysfunction within the contractile proteins that make up the contractile unit often called the sarcomere. Up to now, pharmacological remedy choices usually are not disease-specific and reasonably deal with managing the signs, with out addressing the illness mechanism. Earliest makes an attempt at bettering cardiac contractility by modulating the sarcomere not directly (inotropes) resulted in negative effects. In distinction, concentrating on the sarcomere instantly, aided by high-throughput screening techniques, may establish small molecules with a superior therapeutic worth in cardiac muscle problems.

Herein, an in depth literature assessment of 21 small molecules directed to 5 totally different targets was carried out. A easy scoring system was created to evaluate the suitability of small molecules for remedy by evaluating them in eight totally different standards. A lot of the compounds failed attributable to lack of goal specificity or poor physicochemical properties. Six compounds stood out, exhibiting a possible therapeutic worth in HCM, DCM or coronary heart failure (HF). Omecamtiv Mecarbil and Danicamtiv (myosin activators), Mavacamten, CK-274 and MYK-581 (myosin inhibitors) and AMG 594 (Ca2+-sensitiser) are all small molecules that allosterically modulate troponin or myosin.

 

Omecamtiv Mecarbil confirmed restricted efficacy in part III GALACTIC-HF trial, whereas, outcomes from part III EXPLORER-HCM trial had been lately printed, indicating that Mavacamten diminished left ventricular outflow tract (LVOT) obstruction and diastolic dysfunction and improved the well being standing of sufferers with HCM. A novel class of small molecules often called “recouplers” was reported to focus on a phenomenon termed uncoupling generally present in familial cardiomyopathies however has not progressed past preclinical work. In conclusion, the contractile equipment is a promising goal for brand spanking new drug improvement.

 

VIPERdb v3.0: a structure-based information analytics platform for viral capsids

VIrus Particle ExploreR information base (VIPERdb) (http://viperdb.scripps.edu) is a curated repository of virus capsid buildings and a database of structure-derived information together with numerous virus particular info. VIPERdb has been constantly improved for over 20 years and comprises quite a few virus construction evaluation instruments. The discharge of VIPERdb v3.Zero comprises new structure-based information analytics instruments like A number of Construction-based and Sequence Alignment (MSSA) to establish hot-spot residues inside a particular group of buildings and an anomaly detection utility to research and curate the structure-derived information inside particular person virus households.
On the time of this writing, there are 931 virus buildings from 62 totally different virus households within the database. Considerably, the brand new launch additionally comprises a standalone database known as ‘Virus World database’ (VWdb) that contains all of the characterised viruses (∼181 000) identified up to now, gathered from ICTVdb and NCBI, and their capsid protein sequences, organized in line with their virus taxonomy with hyperlinks to identified buildings in VIPERdb and PDB. Furthermore, the brand new launch of VIPERdb features a service-oriented information engine to deal with all the info entry requests and gives an interface for futuristic information analytics utilizing machine leaning functions.
Publish-transcriptional regulation by way of RNA-binding proteins performs a basic position in each organism, however the regulatory mechanisms lack vital understanding. Nonetheless, they are often elucidated by cross-linking immunoprecipitation together with high-throughput sequencing (CLIP-Seq). CLIP-Seq solutions questions in regards to the useful position of an RNA-binding protein and its targets by figuring out binding websites on a nucleotide degree and related sequence and structural binding patterns. In recent times the quantity of CLIP-Seq information skyrocketed, urging the necessity for an computerized information evaluation that may take care of totally different experimental set-ups. Nevertheless, noncanonical information, new protocols, and an enormous number of instruments, particularly for peak calling, made it tough to outline a normal.
Small Molecules acting on Myofilaments as Treatments for Heart and Skeletal Muscle Diseases

Round RNA Sequencing of Maternal Platelets: A Novel Software for the Identification of Being pregnant-Particular Biomarkers

Within the first trimester of being pregnant, the maternal platelet is instantly concerned in a optimistic suggestions mechanism that facilitates invasion of the extravillous trophoblast into the maternal spiral arteries. Dysfunctional trophoblast invasion with faulty deep placentation is primordial within the etiology of the “nice obstetrical syndromes.”
On this proof-of-concept research, utilizing transcriptome evaluation of round RNA (circRNA) following RNA sequencing of maternal platelets, we examined whether or not pregnancy-specific circRNA markers might be recognized within the first trimester of regular pregnancies. Differential transcript expression evaluation of circRNAs, as predicted by Correct CircRNA Finder Suite, CircRNA Identifier (model 2), and Identified and Novel Isoform Explorer, was finished utilizing thromboSeq.R with variation of a number of settings. Take a look at efficiency was checked for (a) de novo circRNA identification utilizing the novel platelet-specific Plt-circR4 as a optimistic management, (b) full segregation of teams (pregnant vs nonpregnant) after warmth map-dendrogram clustering, (c) identification of pregnancy-specific circRNA markers at a false discovery charge (FDR) <0.05, and (d) affirmation of differentially expressed circRNA markers with an FDR <0.05 by an impartial methodology, reverse transcription-quantitative PCR.

Rabbit Heat Shock Protein 90,HSP-90 ELISA Kit
QY-E30209 96T
EUR 448.8

Rabbit Heat shock protein HSP 90- beta, HSP90AB1 ELISA KIT
ELI-27130Ra 96 Tests
EUR 1113.6

Chicken Heat Shock Protein 90 (HSP-90)
QY-E80144 96T
EUR 511.2

PoFAine Heat Shock Protein 90,HSP-90 ELISA Kit
CN-01297P1 96T
EUR 548.4

PoFAine Heat Shock Protein 90,HSP-90 ELISA Kit
CN-01297P2 48T
EUR 367.2

Chicken Heat Shock Protein 90, HSP-90 ELISA Kit
CSB-E12873C-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Chicken Heat Shock Protein 90, HSP-90 in samples from serum, plasma, tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Chicken Heat Shock Protein 90, HSP-90 ELISA Kit
1-CSB-E12873C
  • EUR 1080.00
  • EUR 6571.20
  • EUR 3480.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Chicken Heat Shock Protein 90, HSP-90 in samples from serum, plasma, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Heat Shock Protein 90, Hsp-90 ELISA Kit
CSB-E08312m-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Mouse Heat Shock Protein 90, Hsp-90 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Heat Shock Protein 90, Hsp-90 ELISA Kit
1-CSB-E08312m
  • EUR 1135.20
  • EUR 6938.40
  • EUR 3672.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse Heat Shock Protein 90, Hsp-90 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Heat Shock Protein 90,Hsp-90 ELISA Kit
CN-02740M1 96T
EUR 548.4

Mouse Heat Shock Protein 90,Hsp-90 ELISA Kit
CN-02740M2 48T
EUR 367.2

Human Heat Shock Protein 90,HSP-90 ELISA Kit
CN-03553H1 96T
EUR 567.6

Human Heat Shock Protein 90,HSP-90 ELISA Kit
CN-03553H2 48T
EUR 387.6

Rat heat shock protein 90,hSP-90 ELISA Kit
CN-01862R1 96T
EUR 538.8

Mouse HSP-90(Heat Shock Protein 90) ELISA Kit
EM1138 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.094 ng/ml

Mouse Heat Shock Protein 90(Hsp-90)ELISA Kit
GA-E0314MS-48T 48T
EUR 403.2

Mouse Heat Shock Protein 90(Hsp-90)ELISA Kit
GA-E0314MS-96T 96T
EUR 640.8

Rat HSP-90(Heat Shock Protein 90) ELISA Kit
ER1058 96T
EUR 571.5
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 75pg/ml

Human Heat Shock Protein 90,HSP-90 ELISA Kit
201-12-1805 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Heat Shock Protein 90(HSP-90)ELISA Kit
GA-E1821HM-48T 48T
EUR 346.8

Human Heat Shock Protein 90(HSP-90)ELISA Kit
GA-E1821HM-96T 96T
EUR 559.2

Rat heat shock protein 90(hSP-90)ELISA Kit
GA-E0531RT-48T 48T
EUR 380.4

Rat heat shock protein 90(hSP-90)ELISA Kit
GA-E0531RT-96T 96T
EUR 595.2

Rat heat shock protein 90(hSP-90)ELISA Kit
QY-E11121 96T
EUR 480

Goat Heat Shock Protein 90 (HSP-90) ELISA Kit
QY-E140075 96T
EUR 495.6

Mouse heat shock protein 90(hSP-90)ELISA Kit
QY-E20717 96T
EUR 433.2

Human Heat Shock Protein 90(HSP-90)ELISA Kit
QY-E01784 96T
EUR 433.2

Porcine heat shock protein 90 (HSP-90) ELISA Kit
QY-E40083 96T
EUR 480

Human Heat shock protein HSP 90-beta (HSP90AB1)
1-CSB-EP010808HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Heat shock protein HSP 90-beta(HSP90AB1) expressed in E.coli

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody
20-abx133116
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody
20-abx134351
  • EUR 427.20
  • EUR 644.40
  • EUR 260.40
  • 100 ul
  • 200 ul
  • 30 ul

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody
abx139528-01mg 0.1 mg
EUR 577.2

Heat Shock Protein HSP 90-Beta (HSP90B) Antibody
20-abx012748
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody
20-abx444869
  • EUR 644.40
  • EUR 410.40
  • 100 ug
  • 25 ug

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody
20-abx445143
  • EUR 560.40
  • EUR 360.00
  • 100 ul
  • 25 ul

Human Heat shock protein HSP 90-beta(HSP90AB1) ELISA kit
CSB-EL010808HU-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Heat shock protein HSP 90-beta (HSP90AB1) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Heat shock protein HSP 90-beta(HSP90AB1) ELISA kit
1-CSB-EL010808HU
  • EUR 964.80
  • EUR 6118.80
  • EUR 3244.80
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Heat shock protein HSP 90-beta(HSP90AB1) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Heat shock protein HSP 90-beta(HSP90AB1) ELISA kit
CSB-EL010808MO-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Mouse Heat shock protein HSP 90-beta (HSP90AB1) in samples from serum, plasma, tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Heat shock protein HSP 90-beta(HSP90AB1) ELISA kit
1-CSB-EL010808MO
  • EUR 964.80
  • EUR 6118.80
  • EUR 3244.80
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse Heat shock protein HSP 90-beta(HSP90AB1) in samples from serum, plasma, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rat Heat shock protein HSP 90-beta(HSP90AB1) ELISA kit
CSB-EL010808RA-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Rat Heat shock protein HSP 90-beta (HSP90AB1) in samples from serum, plasma, tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rat Heat shock protein HSP 90-beta(HSP90AB1) ELISA kit
1-CSB-EL010808RA
  • EUR 964.80
  • EUR 6118.80
  • EUR 3244.80
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rat Heat shock protein HSP 90-beta(HSP90AB1) in samples from serum, plasma, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Heat shock protein HSP 90- beta, Hsp90ab1 ELISA KIT
ELI-31341m 96 Tests
EUR 1038

Human Heat shock protein HSP 90- beta, HSP90AB1 ELISA KIT
ELI-48675h 96 Tests
EUR 988.8

Bovine Heat shock protein HSP 90- beta, HSP90AB1 ELISA KIT
ELI-07968b 96 Tests
EUR 1113.6

Rat Heat shock protein HSP 90-alpha( HSP 90-alpha) ELISA Kit
QY-E11796 96T
EUR 448.8

ELISA kit for Human HSP-90 (Heat Shock Protein 90)
E-EL-H1864 1 plate of 96 wells
EUR 452.4
Description: A sandwich ELISA kit for quantitative measurement of Human HSP-90 (Heat Shock Protein 90) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Mouse HSP-90 (Heat Shock Protein 90)
E-EL-M0620 1 plate of 96 wells
EUR 452.4
Description: A sandwich ELISA kit for quantitative measurement of Mouse HSP-90 (Heat Shock Protein 90) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Rat HSP-90 (Heat Shock Protein 90)
E-EL-R0480 1 plate of 96 wells
EUR 452.4
Description: A sandwich ELISA kit for quantitative measurement of Rat HSP-90 (Heat Shock Protein 90) in samples from Serum, Plasma, Cell supernatant

Rabbit Heat shock protein HSP 90- alpha, HSP90AA1 ELISA KIT
ELI-02919Ra 96 Tests
EUR 1113.6

Human Heat Shock Protein 90 (HSP-90) CLIA Kit
abx195773-96tests 96 tests
EUR 990

Mouse Heat Shock Protein 90 (HSP-90) CLIA Kit
abx195774-96tests 96 tests
EUR 990

Rat Heat Shock Protein 90 (HSP-90) CLIA Kit
abx195775-96tests 96 tests
EUR 990

HSP-90 ELISA Kit| Rat Heat Shock Protein 90 ELISA Kit
EF017815 96 Tests
EUR 826.8

HSP-90 ELISA Kit| Mouse Heat Shock Protein 90 ELISA Kit
EF013694 96 Tests
EUR 826.8

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (Biotin)
abx442835-100ug 100 ug
EUR 710.4

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (FITC)
abx443115-100ug 100 ug
EUR 710.4

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (HRP)
abx443395-100ug 100 ug
EUR 693.6

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (PerCP)
abx443957-100ug 100 ug
EUR 710.4

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (RPE)
abx444238-100ug 100 ug
EUR 710.4

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (Streptavidin)
abx444519-100ug 100 ug
EUR 710.4

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (ALP)
abx445719-100ul 100 ul
EUR 610.8

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (APC)
abx445721-100ul 100 ul
EUR 627.6

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (PerCP)
abx445731-100ul 100 ul
EUR 627.6

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (RPE)
abx445733-100ul 100 ul
EUR 627.6

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (Streptavidin)
abx445735-100ul 100 ul
EUR 627.6

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (ALP)
abx442273-100ug 100 ug
EUR 710.4

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (APC)
abx442554-100ug 100 ug
EUR 710.4

Human Total HSP-90(Heat Shock Protein 90 total) ELISA Kit
EH4266 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 46.875pg/ml

Human Heat Shock Protein 90 total (Total HSP-90) ELISA Kit
abx257311-96tests 96 tests
EUR 764.4

Rat heat shock protein 90,hSP-91 ELISA Kit
CN-01862R2 48T
EUR 358.8

CLIA kit for Human HSP-90 (Heat Shock Protein 90)
E-CL-H1154 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Human HSP-90 (Heat Shock Protein 90) in samples from Serum, Plasma, Cell supernatant

CLIA kit for Mouse HSP-90 (Heat Shock Protein 90)
E-CL-M0376 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Mouse HSP-90 (Heat Shock Protein 90) in samples from Serum, Plasma, Cell supernatant

CLIA kit for Rat HSP-90 (Heat Shock Protein 90)
E-CL-R0327 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Rat HSP-90 (Heat Shock Protein 90) in samples from Serum, Plasma, Cell supernatant

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (ATTO 390)
abx440025-100ug 100 ug
EUR 710.4

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (ATTO 390)
abx445703-100ul 100 ul
EUR 627.6

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (ATTO 488)
abx445705-100ul 100 ul
EUR 627.6

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (ATTO 565)
abx445707-100ul 100 ul
EUR 627.6

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (ATTO 594)
abx445709-100ul 100 ul
EUR 627.6

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (ATTO 633)
abx445711-100ul 100 ul
EUR 627.6

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (ATTO 655)
abx445713-100ul 100 ul
EUR 627.6

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (ATTO 680)
abx445715-100ul 100 ul
EUR 627.6

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (ATTO 700)
abx445717-100ul 100 ul
EUR 627.6

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (ATTO 488)
abx440306-100ug 100 ug
EUR 710.4

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (ATTO 565)
abx440587-100ug 100 ug
EUR 710.4

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (ATTO 594)
abx440868-100ug 100 ug
EUR 710.4

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (ATTO 633)
abx441149-100ug 100 ug
EUR 710.4

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (ATTO 655)
abx441430-100ug 100 ug
EUR 710.4

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (ATTO 680)
abx441711-100ug 100 ug
EUR 710.4

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (ATTO 700)
abx441992-100ug 100 ug
EUR 710.4

Rabbit Heat Shock Protein 90 ELISA kit
E04H0304-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit Heat Shock Protein 90 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Heat Shock Protein 90 ELISA kit
E04H0304-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit Heat Shock Protein 90 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Heat Shock Protein 90 ELISA kit
E04H0304-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit Heat Shock Protein 90 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Heat Shock Protein 90 ELISA Kit
ELA-E0863Rb 96 Tests
EUR 1113.6

Bovine HSP90AA1/ Heat shock protein HSP 90-alpha ELISA Kit
E0125Bo 1 Kit
EUR 860.4

Bovine Heat shock protein HSP 90-alpha(HSP90AA1) ELISA kit
CSB-EL010802BO-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Bovine Heat shock protein HSP 90-alpha (HSP90AA1) in samples from serum, plasma, tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Bovine Heat shock protein HSP 90-alpha(HSP90AA1) ELISA kit
1-CSB-EL010802BO
  • EUR 1080.00
  • EUR 6571.20
  • EUR 3480.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Bovine Heat shock protein HSP 90-alpha(HSP90AA1) in samples from serum, plasma, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rat Hsp90aa1/ Heat shock protein HSP 90-alpha ELISA Kit
E0470Ra 1 Kit
EUR 685.2

Human HSP90AA1/ Heat shock protein HSP 90-alpha ELISA Kit
E1174Hu 1 Kit
EUR 685.2

ELISA kit for Human Heat shock protein HSP 90-alpha
EK2369 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Heat shock protein HSP 90-alpha in samples from serum, plasma, tissue homogenates and other biological fluids.

Human Heat Shock Protein HSP 90 Alpha (HSP90AA1) ELISA Kit
abx250315-96tests 96 tests
EUR 764.4

Human HSP90AA1(Heat shock protein HSP 90-alpha) ELISA Kit
EH1072 96T
EUR 571.5
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 1.875 ng/ml

Human Heat shock protein HSP 90- alpha, HSP90AA1 ELISA KIT
ELI-02918h 96 Tests
EUR 988.8

Chicken Heat shock protein HSP 90- alpha, HSP90AA1 ELISA KIT
ELI-02920c 96 Tests
EUR 1113.6

Bovine Heat shock protein HSP 90- alpha, HSP90AA1 ELISA KIT
ELI-02922b 96 Tests
EUR 1113.6

Mouse Heat shock protein HSP 90- alpha, Hsp90aa1 ELISA KIT
ELI-02923m 96 Tests
EUR 1038

Porcine Heat shock protein HSP 90- alpha, HSP90AA1 ELISA KIT
ELI-02924p 96 Tests
EUR 1113.6

Bovine Heat shock protein HSP 90-alpha(HSP90AA1) ELISA Kit
QY-E60085 96T
EUR 511.2

Human Heat shock protein HSP 90-alpha (HSP90AA1)
1-CSB-EP010802HU1
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Heat shock protein HSP 90-alpha(HSP90AA1),partial expressed in E.coli

Human Heat shock protein HSP 90-alpha (HSP90AA1)
1-CSB-YP010802HU1
  • EUR 516.00
  • EUR 280.80
  • EUR 1809.60
  • EUR 770.40
  • EUR 1210.80
  • EUR 349.20
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Heat shock protein HSP 90-alpha(HSP90AA1),partial expressed in Yeast

Pig Heat shock protein HSP 90-alpha (HSP90AA1)
1-CSB-BP010802PI
  • EUR 913.20
  • EUR 367.20
  • EUR 2341.20
  • EUR 1231.20
  • EUR 1706.40
  • EUR 517.20
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Pig Heat shock protein HSP 90-alpha(HSP90AA1),partial expressed in Baculovirus

Heat Shock Protein HSP 90-Alpha (HSP90A) Antibody
20-abx134349
  • EUR 427.20
  • EUR 644.40
  • EUR 260.40
  • 100 ul
  • 200 ul
  • 30 ul

Heat Shock Protein HSP 90-Alpha (HSP90A) Antibody
20-abx134350
  • EUR 427.20
  • EUR 644.40
  • EUR 260.40
  • 100 ul
  • 200 ul
  • 30 ul

Heat Shock Protein HSP 90-Alpha (HSP90A) Antibody
20-abx137351
  • EUR 844.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 20 ug
  • 5 ug

Heat Shock Protein HSP 90-Alpha (HSP90A) Antibody
20-abx009143
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Heat Shock Protein HSP 90-Alpha (HSP90A) Antibody
20-abx444849
  • EUR 644.40
  • EUR 260.40
  • EUR 410.40
  • 100 ug
  • 12 µg
  • 25 ug

Heat Shock Protein HSP 90-Alpha (HSP90A) Antibody
20-abx444877
  • EUR 644.40
  • EUR 410.40
  • 200 ug
  • 50 ug

Recombinant human Heat shock protein HSP 90-alpha
P1211 100ug Ask for price
Description: Recombinant protein for human Heat shock protein HSP 90-alpha

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (PE/ATTO 594)
abx443676-100ug 100 ug
EUR 727.2

Heat Shock Protein HSP 90-Beta (HSP90AB1) Antibody (PE/ATTO 594)
abx445729-100ul 100 ul
EUR 627.6

Rabbit Heat shock protein 90 Alpha ELISA kit
E04H0305-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit Heat shock protein 90 Alpha in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Heat shock protein 90 Alpha ELISA kit
E04H0305-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit Heat shock protein 90 Alpha in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Heat shock protein 90 Alpha ELISA kit
E04H0305-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit Heat shock protein 90 Alpha in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Heat Shock Protein 90 (HSP90) ELISA Kit
abx362603-96tests 96 tests
EUR 904.8

Heat Shock Protein HSP 90-Alpha (HSP90A) Antibody (Biotin)
abx442815-100ug 100 ug
EUR 710.4

Heat Shock Protein HSP 90-Alpha (HSP90A) Antibody (Biotin)
abx442843-200ug 200 ug
EUR 760.8

Heat Shock Protein HSP 90-Alpha (HSP90A) Antibody (FITC)
abx443095-100ug 100 ug
EUR 710.4

Heat Shock Protein HSP 90-Alpha (HSP90A) Antibody (FITC)
abx443123-200ug 200 ug
EUR 744

Heat Shock Protein HSP 90-Alpha (HSP90A) Antibody (HRP)
abx443375-100ug 100 ug
EUR 693.6

Heat Shock Protein HSP 90-Alpha (HSP90A) Antibody (HRP)
abx443403-200ug 200 ug
EUR 744

Heat Shock Protein HSP 90-Alpha (HSP90A) Antibody (PerCP)
abx443937-100ug 100 ug
EUR 710.4

Heat Shock Protein HSP 90-Alpha (HSP90A) Antibody (PerCP)
abx443965-200ug 200 ug
EUR 777.6

Heat Shock Protein HSP 90-Alpha (HSP90A) Antibody (RPE)
abx444218-100ug 100 ug
EUR 710.4

Heat Shock Protein HSP 90-Alpha (HSP90A) Antibody (RPE)
abx444246-200ug 200 ug
EUR 760.8

Heat Shock Protein HSP 90-Alpha (HSP90A) Antibody (Streptavidin)
abx444499-100ug 100 ug
EUR 710.4

Heat Shock Protein HSP 90-Alpha (HSP90A) Antibody (Streptavidin)
abx444527-200ug 200 ug
EUR 760.8

Heat Shock Protein HSP 90-Alpha (HSP90A) Antibody (ALP)
abx442253-100ug 100 ug
EUR 710.4

Heat Shock Protein HSP 90-Alpha (HSP90A) Antibody (ALP)
abx442281-200ug 200 ug
EUR 760.8

Heat Shock Protein HSP 90-Alpha (HSP90A) Antibody (APC)
abx442534-100ug 100 ug
EUR 710.4

Heat Shock Protein HSP 90-Alpha (HSP90A) Antibody (APC)
abx442562-200ug 200 ug
EUR 777.6

Rabbit HSP-90 ELISA Kit
ERTH0311 96Tests
EUR 625.2

Rabbit Heat Shock Protein 70,HSP-70 ELISA Kit
CN-00635R1 96T
EUR 553.2

Rabbit Heat Shock Protein 70,HSP-70 ELISA Kit
CN-00635R2 48T
EUR 372

Rabbit Heat Shock Protein 40,HSP-40 ELISA Kit
CN-00636R1 96T
EUR 553.2

Rabbit Heat Shock Protein 40,HSP-40 ELISA Kit
CN-00636R2 48T
EUR 372

Rabbit Heat Shock Protein 20,HSP-20 ELISA Kit
CN-00637R1 96T
EUR 553.2

Rabbit Heat Shock Protein 20,HSP-20 ELISA Kit
CN-00637R2 48T
EUR 372

Rabbit Heat Shock Protein 20 HSP 20 ELISA kit
E04H0285-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rabbit Heat Shock Protein 20 HSP 20 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Heat Shock Protein 20 HSP 20 ELISA kit
E04H0285-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rabbit Heat Shock Protein 20 HSP 20 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Heat Shock Protein 20 HSP 20 ELISA kit
E04H0285-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rabbit Heat Shock Protein 20 HSP 20 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Heat Shock Protein 70 HSP-70 ELISA kit
E04H0301-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rabbit Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Heat Shock Protein 70 HSP-70 ELISA kit
E04H0301-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rabbit Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Heat Shock Protein 70 HSP-70 ELISA kit
E04H0301-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rabbit Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Heat Shock Protein 20,HSP-20 ELISA Kit
GA-E0087RB-48T 48T
EUR 391.2

Rabbit Heat Shock Protein 20,HSP-20 ELISA Kit
GA-E0087RB-96T 96T
EUR 628.8

Rabbit Heat Shock Protein 40,HSP-40 ELISA Kit
GA-E0088RB-48T 48T
EUR 391.2

Rabbit Heat Shock Protein 40,HSP-40 ELISA Kit
GA-E0088RB-96T 96T
EUR 628.8

Rabbit Heat Shock Protein 70,HSP-70 ELISA Kit
GA-E0089RB-48T 48T
EUR 391.2

Rabbit Heat Shock Protein 70,HSP-70 ELISA Kit
GA-E0089RB-96T 96T
EUR 628.8

Rabbit Heat Shock Protein 70,HSP-70 ELISA Kit
QY-E30210 96T
EUR 448.8

Rabbit Heat Shock Protein 40,HSP-40 ELISA Kit
QY-E30211 96T
EUR 448.8

Rabbit Heat Shock Protein 20,HSP-20 ELISA Kit
QY-E30212 96T
EUR 448.8

HSP-90/ Rat HSP- 90 ELISA Kit
ELA-E0863r 96 Tests
EUR 1063.2

Rat Heat shock protein HSP 90-alpha (Hsp90aa1/Hsp86/Hspca) ELISA kit
CSB-E08309r-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Rat Heat shock protein HSP 90-alpha (Hsp90aa1/Hsp86/Hspca) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rat Heat shock protein HSP 90-alpha (Hsp90aa1/Hsp86/Hspca) ELISA kit
1-CSB-E08309r
  • EUR 1160.40
  • EUR 7110.00
  • EUR 3760.80
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rat Heat shock protein HSP 90-alpha (Hsp90aa1/Hsp86/Hspca) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Heat Shock Protein (hsp) Fragment
H-8400.0001 1.0mg
EUR 675.6
Description: Sum Formula: C63H113N22O25PS; CAS# [165245-21-6] net

Heat Shock Protein (hsp) Fragment
H-8400.0005 5.0mg
EUR 2590.8
Description: Sum Formula: C63H113N22O25PS; CAS# [165245-21-6] net

ELISA kit for Human HSP?6/HSP-20 (Heat Shock Protein Beta 6)
E-EL-H1859 1 plate of 96 wells
EUR 452.4
Description: A sandwich ELISA kit for quantitative measurement of Human HSP?6/HSP-20 (Heat Shock Protein Beta 6) in samples from Serum, Plasma, Cell supernatant

Heat Shock Protein HSP 90-Alpha (HSP90A) Antibody (ATTO 390)
abx440005-100ug 100 ug
EUR 710.4

Heat Shock Protein HSP 90-Alpha (HSP90A) Antibody (ATTO 390)
abx440033-200ug 200 ug
EUR 777.6

Heat Shock Protein HSP 90-Alpha (HSP90A) Antibody (ATTO 488)
abx440286-100ug 100 ug
EUR 710.4

Heat Shock Protein HSP 90-Alpha (HSP90A) Antibody (ATTO 488)
abx440314-200ug 200 ug
EUR 777.6

Heat Shock Protein HSP 90-Alpha (HSP90A) Antibody (ATTO 565)
abx440567-100ug 100 ug
EUR 710.4

Heat Shock Protein HSP 90-Alpha (HSP90A) Antibody (ATTO 565)
abx440595-200ug 200 ug
EUR 777.6

Heat Shock Protein HSP 90-Alpha (HSP90A) Antibody (ATTO 594)
abx440848-100ug 100 ug
EUR 710.4

Heat Shock Protein HSP 90-Alpha (HSP90A) Antibody (ATTO 594)
abx440876-200ug 200 ug
EUR 777.6
Of the differentially expressed circRNAs with P values <0.05, 41 circRNAs had been upregulated (logFC >2), and 52 circRNAs had been downregulated (logFC lower than -2) in first-trimester platelet RNA. Of those, nuclear receptor-interacting protein 1 circRNA protecting exons 2 and three of the 5′-untranslated area was being pregnant particular with upregulation in first-trimester maternal platelets in comparison with nonpregnant controls.

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