Discovery of novel isoliquiritigenin analogue ISL-17 as a potential anti-gastric cancer agent

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Discovery of novel isoliquiritigenin analogue ISL-17 as a potential anti-gastric cancer agent

Isoliquiritigenin (ISL), a pure product remoted from licorice root, displays anti-gastric most cancers results. Nevertheless, purposes of ISL are nonetheless restricted in scientific follow as a result of its poor bioavailability. To discovery of more practical anti-gastric most cancers brokers primarily based on ISL, aldol condensation response was utilized to synthesize the ISL analogues. MTS assay was used to guage the inhibitory actions of ISL analogues towards SGC-7901, BGC-823 and GES-1 cells in vitro. Cell cycle distribution, apoptosis and reactive oxygen species (ROS) era had been detected by move cytometry.

Western blot assay was used to investigate the expression ranges of associated proteins. The drug-likeness and pharmacokinetic properties had been predicted with Osiris property explorer and PreADMET server. In consequence, 18 new ISL analogues (ISL-1 to ISL-18) had been synthesized. Amongst these analogues, ISL-17 confirmed the strongest inhibitory actions towards SGC-7901 and BGC-823 cells, and will induce G2/M cell cycle arrest and apoptosis in these two cell traces. Remedy with ISL-17 resulted in elevated ROS manufacturing and elevated autophagy ranges in SGC-7901 cells.

The PI3K/AKT/mTOR signaling pathway was down-regulated after remedy with ISL-17 in SGC-7901 cells. The outcomes of drug-likeness and pharmacokinetic prediction indicated that every one the ISL analogues complied with Lipinski’s rule of 5 and Veber rule and had a good ADME character. Total, our outcomes attest that ISL-17 holds promise as a candidate agent towards gastric most cancers.

Analyzing the prognostic worth of DKK1 expression in human cancers primarily based on bioinformatics.

The Dickkopf1 (DKK1) gene encodes a protein that belongs to the Dickkopf household. The protein can inhibit the Wnt signaling pathway which performs a key function within the carcinogenesis and development of assorted forms of cancers. Based mostly on this, we hypothesized that the differential expression of DKK1 could determine considerably in cancers by regulating Wnt signaling pathway transduction. On this research, we carried out bioinformatics evaluation to guage the prognostic and therapeutic worth of DKK1 expression degree in human cancers.

The expression degree was analyzed by utilizing the Oncomine database and Gene Expression Profiling Interactive Evaluation device. The evaluation of prognosis was carried out by utilizing the UALCAN, Gene Expression Profiling Interactive Evaluation (GEPIA), and DriverDBv3 databases. We additionally investigated utilizing DKK1 promoter methylation to outline most cancers sorts via the UALCAN database. In the meantime, the associated purposeful networks of DKK1 had been analyzed by utilizing the GeneMANIA interactive device and Cytoscape software program. Moreover, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway evaluation was carried out utilizing the Metascape on-line web site, and we used the cBioPotartal database to explored DKK1 expression, aberrant data, and the co-expression genes within the subgroups of lung most cancers. Lastly, we carried out the general survival (OS) meta-analysis of the DKK1 expression in lung squamous cell carcinoma (LUSC) by way of the Lung Most cancers Explorer (LCE).DKK1 was differentially expressed in several types of human cancers. DKK1 was overexpressed in human cancers together with head and neck squamous cell carcinoma (HNSC), LUSC, and pancreatic adenocarcinoma (PAAD).

Overexpression of DKK1 indicated adversarial OS in bladder urothelial carcinoma (BLCA), HNSC, and PADD, however no distinction in OS was discovered between the LUSC and wholesome teams. The excessive expression of DKK1 was additionally related to shorter disease-free survival (DFS) in HNSC, LUSC, and PAAD. Gene regulation community evaluation indicated that DKK1 was primarily concerned in Wnt signaling pathways and a number of other different signaling pathways.Our findings confirmed that DKK1 is considerably expressed in varied cancers and may very well be a biomarker for focused remedy and a predictor for prognosis of those particular cancers.
The bioinformatics evaluation revealed a big overexpression of DKK1 in HNSC, LUSC, and PAAD, with DKK1 overexpression being related to adversarial end result in these sufferers, however how DKK1 expression ranges relate to hematological malignancies and prognosis remains to be unclear. These new insights into the perform of DKK1 could present a foundation for brand new focused drug remedy and an avenue for additional investigation into the mechanisms underlying carcinogenesis of DKK1 in several most cancers sorts.Discovery of novel isoliquiritigenin analogue ISL-17 as a potential anti-gastric cancer agent

Genetic and structural research of RABL3 reveal a vital function in lymphoid growth and performance.

The small GTPase RABL3 is an oncogene of unknown physiological perform. Homozygous knockout alleles of mouse Rabl3 had been embryonic deadly, however a viable hypomorphic allele (xiamen [xm]) inflicting in-frame deletion of 4 amino acids from the interswitch area resulted in profound defects in lymphopoiesis. Impaired lymphoid progenitor growth led to deficiencies of B cells, T cells, and pure killer (NK) cells in Rabl3xm/xm mice. T cells and NK cells exhibited impaired cytolytic exercise, and mice contaminated with mouse cytomegalovirus (MCMV) displayed elevated titers within the spleen.
Myeloid cells had been regular in quantity and performance. Biophysical and crystallographic research demonstrated that RABL3 fashioned a homodimer in resolution by way of interactions between the effector binding surfaces on every subunit; monomers adopted a typical small G protein fold. RABL3xm displayed a big compensatory alteration in swap I, which adopted a β-strand configuration usually supplied by the deleted interswitch residues, thereby allowing homodimer formation.

Coiled Coil Domain Containing Protein 60 (CCDC60) Antibody
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Coiled Coil Domain Containing Protein 60 (CCDC60) Antibody
abx104218-100g 100 µg
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Coiled Coil Domain Containing Protein 60 (CCDC60) Antibody
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Coiled Coil Domain Containing Protein 60 (CCDC60) Antibody
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Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody
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Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody
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PAU807Hu01 100ul
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Monoclonal Antibody to Coiled Coil Domain Containing Protein 60 (CCDC60)
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Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Rat)
4-PAU807Ra01
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Description: A Rabbit polyclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60)

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4-MAU807Ra21
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Description: A Mouse monoclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60)

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4-PAU807Hu01
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Description: A Rabbit polyclonal antibody against Human Coiled Coil Domain Containing Protein 60 (CCDC60)

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4-PAU807Mu01
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Description: A Rabbit polyclonal antibody against Mouse Coiled Coil Domain Containing Protein 60 (CCDC60)

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4-PAU807Ra01-APC
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Description: A Rabbit polyclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with APC.

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4-PAU807Ra01-Cy3
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Description: A Rabbit polyclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with Cy3.

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4-PAU807Ra01-HRP
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Description: A Rabbit polyclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with HRP.

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4-PAU807Ra01-PE
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Description: A Rabbit polyclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with PE.

Coiled Coil Domain Containing Protein 60 (CCDC60) Monoclonal Antibody (Rat), APC
4-MAU807Ra21-APC
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Description: A Mouse monoclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with APC.

Coiled Coil Domain Containing Protein 60 (CCDC60) Monoclonal Antibody (Rat), Cy3
4-MAU807Ra21-Cy3
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Description: A Mouse monoclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with Cy3.

Coiled Coil Domain Containing Protein 60 (CCDC60) Monoclonal Antibody (Rat), HRP
4-MAU807Ra21-HRP
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Description: A Mouse monoclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with HRP.

Coiled Coil Domain Containing Protein 60 (CCDC60) Monoclonal Antibody (Rat), PE
4-MAU807Ra21-PE
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Description: A Mouse monoclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with PE.

Biotin-Linked Antibody to Coiled Coil Domain Containing Protein 60 (CCDC60)
MBS2004754-01mL 0.1mL
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Biotin-Linked Antibody to Coiled Coil Domain Containing Protein 60 (CCDC60)
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Biotin-Linked Antibody to Coiled Coil Domain Containing Protein 60 (CCDC60)
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Biotin-Linked Antibody to Coiled Coil Domain Containing Protein 60 (CCDC60)
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Biotin-Linked Antibody to Coiled Coil Domain Containing Protein 60 (CCDC60)
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Biotin-Linked Antibody to Coiled Coil Domain Containing Protein 60 (CCDC60)
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Biotin-Linked Antibody to Coiled Coil Domain Containing Protein 60 (CCDC60)
MBS2007031-02mL 0.2mL
EUR 250

Biotin-Linked Antibody to Coiled Coil Domain Containing Protein 60 (CCDC60)
MBS2007031-05mL 0.5mL
EUR 430

Biotin-Linked Antibody to Coiled Coil Domain Containing Protein 60 (CCDC60)
MBS2007031-1mL 1mL
EUR 525

Biotin-Linked Antibody to Coiled Coil Domain Containing Protein 60 (CCDC60)
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Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Human), APC
4-PAU807Hu01-APC
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Description: A Rabbit polyclonal antibody against Human Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with APC.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Human), Cy3
4-PAU807Hu01-Cy3
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Description: A Rabbit polyclonal antibody against Human Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with Cy3.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Human), HRP
4-PAU807Hu01-HRP
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Description: A Rabbit polyclonal antibody against Human Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with HRP.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Human), PE
4-PAU807Hu01-PE
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Description: A Rabbit polyclonal antibody against Human Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with PE.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Mouse), APC
4-PAU807Mu01-APC
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Description: A Rabbit polyclonal antibody against Mouse Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with APC.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Mouse), Cy3
4-PAU807Mu01-Cy3
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Description: A Rabbit polyclonal antibody against Mouse Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with Cy3.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Mouse), HRP
4-PAU807Mu01-HRP
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Description: A Rabbit polyclonal antibody against Mouse Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with HRP.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Mouse), PE
4-PAU807Mu01-PE
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Description: A Rabbit polyclonal antibody against Mouse Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with PE.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Rat), FITC
4-PAU807Ra01-FITC
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Description: A Rabbit polyclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with FITC.

Coiled Coil Domain Containing Protein 60 (CCDC60) Monoclonal Antibody (Rat), FITC
4-MAU807Ra21-FITC
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Description: A Mouse monoclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with FITC.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Human), FITC
4-PAU807Hu01-FITC
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Description: A Rabbit polyclonal antibody against Human Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with FITC.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Mouse), FITC
4-PAU807Mu01-FITC
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Description: A Rabbit polyclonal antibody against Mouse Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with FITC.

Coiled Coil Domain Containing Protein 3 (CCDC3) Antibody
20-abx128391
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Coiled Coil Domain Containing Protein 3 (CCDC3) Antibody
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Coiled Coil Domain Containing Protein 3 (CCDC3) Antibody
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Coiled Coil Domain Containing Protein 3 (CCDC3) Antibody
abx128391-1ml 1 ml
EUR 825

Coiled Coil Domain Containing Protein 3 (CCDC3) Antibody
abx128391-200l 200 µl
EUR 362.5

Coiled Coil Domain Containing Protein 3 (CCDC3) Antibody
abx171827-1ml 1 ml
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Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Rat), Biotinylated
4-PAU807Ra01-Biotin
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Description: A Rabbit polyclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with Biotin.

Coiled Coil Domain Containing Protein 60 (CCDC60) Monoclonal Antibody (Rat), Biotinylated
4-MAU807Ra21-Biotin
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Description: A Mouse monoclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with Biotin.

Coiled Coil Domain Containing Protein 80 (CCDC80) Antibody
20-abx104220
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Coiled Coil Domain Containing Protein 80 (CCDC80) Antibody
20-abx104221
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Coiled Coil Domain Containing Protein 80 (CCDC80) Antibody
20-abx104222
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Coiled Coil Domain Containing Protein 80 (CCDC80) Antibody
abx104220-100g 100 µg
EUR 750

Coiled Coil Domain Containing Protein 80 (CCDC80) Antibody
abx104220-20g 20 µg
EUR 275

Coiled Coil Domain Containing Protein 80 (CCDC80) Antibody
abx104220-50g 50 µg
EUR 337.5

Coiled Coil Domain Containing Protein 80 (CCDC80) Antibody
abx104221-100g 100 µg
EUR 750

Coiled Coil Domain Containing Protein 80 (CCDC80) Antibody
abx104221-20g 20 µg
EUR 275

Coiled Coil Domain Containing Protein 80 (CCDC80) Antibody
abx104221-50g 50 µg
EUR 337.5

Coiled Coil Domain Containing Protein 80 (CCDC80) Antibody
abx104222-100g 100 µg
EUR 812.5

Coiled Coil Domain Containing Protein 80 (CCDC80) Antibody
abx104222-20g 20 µg
EUR 287.5

Coiled Coil Domain Containing Protein 80 (CCDC80) Antibody
abx104222-50g 50 µg
EUR 362.5

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Rat), APC-Cy7
4-PAU807Ra01-APC-Cy7
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Description: A Rabbit polyclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with APC-Cy7.

Coiled Coil Domain Containing Protein 60 (CCDC60) Monoclonal Antibody (Rat), APC-Cy7
4-MAU807Ra21-APC-Cy7
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Description: A Mouse monoclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with APC-Cy7.

PE-Linked Polyclonal Antibody to Coiled Coil Domain Containing Protein 60 (CCDC60)
MBS2085695-01mL 0.1mL
EUR 290

PE-Linked Polyclonal Antibody to Coiled Coil Domain Containing Protein 60 (CCDC60)
MBS2085695-02mL 0.2mL
EUR 385

PE-Linked Polyclonal Antibody to Coiled Coil Domain Containing Protein 60 (CCDC60)
MBS2085695-05mL 0.5mL
EUR 715

PE-Linked Polyclonal Antibody to Coiled Coil Domain Containing Protein 60 (CCDC60)
MBS2085695-1mL 1mL
EUR 885

PE-Linked Polyclonal Antibody to Coiled Coil Domain Containing Protein 60 (CCDC60)
MBS2085695-5mL 5mL
EUR 2550

PE-Linked Polyclonal Antibody to Coiled Coil Domain Containing Protein 60 (CCDC60)
MBS2085701-01mL 0.1mL
EUR 295

PE-Linked Polyclonal Antibody to Coiled Coil Domain Containing Protein 60 (CCDC60)
MBS2085701-02mL 0.2mL
EUR 395

PE-Linked Polyclonal Antibody to Coiled Coil Domain Containing Protein 60 (CCDC60)
MBS2085701-05mL 0.5mL
EUR 740

PE-Linked Polyclonal Antibody to Coiled Coil Domain Containing Protein 60 (CCDC60)
MBS2085701-1mL 1mL
EUR 910

PE-Linked Polyclonal Antibody to Coiled Coil Domain Containing Protein 60 (CCDC60)
MBS2085701-5mL 5mL
EUR 2630

PE-Linked Polyclonal Antibody to Coiled Coil Domain Containing Protein 60 (CCDC60)
MBS2085707-01mL 0.1mL
EUR 305

PE-Linked Polyclonal Antibody to Coiled Coil Domain Containing Protein 60 (CCDC60)
MBS2085707-02mL 0.2mL
EUR 415

PE-Linked Polyclonal Antibody to Coiled Coil Domain Containing Protein 60 (CCDC60)
MBS2085707-05mL 0.5mL
EUR 775

PE-Linked Polyclonal Antibody to Coiled Coil Domain Containing Protein 60 (CCDC60)
MBS2085707-1mL 1mL
EUR 960

PE-Linked Polyclonal Antibody to Coiled Coil Domain Containing Protein 60 (CCDC60)
MBS2085707-5mL 5mL
EUR 2750

PE-Linked Monoclonal Antibody to Coiled Coil Domain Containing Protein 60 (CCDC60)
MBS2110970-INQUIRE INQUIRE Ask for price

Rat Coiled Coil Domain Containing Protein 60 (CCDC60) Protein
20-abx065994
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Rat Coiled Coil Domain Containing Protein 60 (CCDC60) Protein
abx065994-100g 100 µg
EUR 550

Rat Coiled Coil Domain Containing Protein 60 (CCDC60) Protein
abx065994-10g 10 µg
EUR 212.5

Rat Coiled Coil Domain Containing Protein 60 (CCDC60) Protein
abx065994-50g 50 µg
EUR 387.5

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Human), Biotinylated
4-PAU807Hu01-Biotin
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with Biotin.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Mouse), Biotinylated
4-PAU807Mu01-Biotin
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with Biotin.

Recombinant Coiled Coil Domain Containing Protein 60 (CCDC60)
RPU53470-100ug 100ug
EUR 552.2

Recombinant Coiled Coil Domain Containing Protein 60 (CCDC60)
RPU53470-1mg 1mg
EUR 2446.6

Recombinant Coiled Coil Domain Containing Protein 60 (CCDC60)
RPU53470-50ug 50ug
EUR 443.3

Recombinant Coiled Coil Domain Containing Protein 60 (CCDC60)
RPU40887-100ug 100ug
EUR 616

Recombinant Coiled Coil Domain Containing Protein 60 (CCDC60)
RPU40887-1mg 1mg
EUR 2730

Recombinant Coiled Coil Domain Containing Protein 60 (CCDC60)
RPU40887-50ug 50ug
EUR 495

Recombinant Coiled Coil Domain Containing Protein 60 (CCDC60)
RPU40888-100ug 100ug
EUR 517

Recombinant Coiled Coil Domain Containing Protein 60 (CCDC60)
RPU40888-1mg 1mg
EUR 2293.2

Recombinant Coiled Coil Domain Containing Protein 60 (CCDC60)
RPU40888-50ug 50ug
EUR 415.8

Recombinant Coiled Coil Domain Containing Protein 60 (CCDC60)
RPU807Hu01 10ug
EUR 179

Recombinant Coiled Coil Domain Containing Protein 60 (CCDC60)
4-RPU807Hu01
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  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Coiled Coil Domain Containing Protein 60 expressed in: E.coli

Recombinant Coiled Coil Domain Containing Protein 60 (CCDC60)
RPU807Mu01 10ug
EUR 200
Dysregulated effector binding as a result of conformational adjustments within the swap I-interswitch-switch II module possible underlies the xm phenotype. One such effector could also be GPR89, putatively an ion channel or G protein-coupled receptor (GPCR). RABL3, however not RABL3xm, strongly related to and stabilized GPR89, and an N-ethyl-N-nitrosourea (ENU)-induced mutation (explorer) in Gpr89 phenocopied Rabl3xm.

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