Discovery of novel isoliquiritigenin analogue ISL-17 as a potential anti-gastric cancer agent

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Discovery of novel isoliquiritigenin analogue ISL-17 as a potential anti-gastric cancer agent

Isoliquiritigenin (ISL), a pure product remoted from licorice root, displays anti-gastric most cancers results. Nevertheless, purposes of ISL are nonetheless restricted in scientific follow as a result of its poor bioavailability. To discovery of more practical anti-gastric most cancers brokers primarily based on ISL, aldol condensation response was utilized to synthesize the ISL analogues. MTS assay was used to guage the inhibitory actions of ISL analogues towards SGC-7901, BGC-823 and GES-1 cells in vitro. Cell cycle distribution, apoptosis and reactive oxygen species (ROS) era had been detected by move cytometry.

Western blot assay was used to investigate the expression ranges of associated proteins. The drug-likeness and pharmacokinetic properties had been predicted with Osiris property explorer and PreADMET server. In consequence, 18 new ISL analogues (ISL-1 to ISL-18) had been synthesized. Amongst these analogues, ISL-17 confirmed the strongest inhibitory actions towards SGC-7901 and BGC-823 cells, and will induce G2/M cell cycle arrest and apoptosis in these two cell traces. Remedy with ISL-17 resulted in elevated ROS manufacturing and elevated autophagy ranges in SGC-7901 cells.

The PI3K/AKT/mTOR signaling pathway was down-regulated after remedy with ISL-17 in SGC-7901 cells. The outcomes of drug-likeness and pharmacokinetic prediction indicated that every one the ISL analogues complied with Lipinski’s rule of 5 and Veber rule and had a good ADME character. Total, our outcomes attest that ISL-17 holds promise as a candidate agent towards gastric most cancers.

Analyzing the prognostic worth of DKK1 expression in human cancers primarily based on bioinformatics.

The Dickkopf1 (DKK1) gene encodes a protein that belongs to the Dickkopf household. The protein can inhibit the Wnt signaling pathway which performs a key function within the carcinogenesis and development of assorted forms of cancers. Based mostly on this, we hypothesized that the differential expression of DKK1 could determine considerably in cancers by regulating Wnt signaling pathway transduction. On this research, we carried out bioinformatics evaluation to guage the prognostic and therapeutic worth of DKK1 expression degree in human cancers.

The expression degree was analyzed by utilizing the Oncomine database and Gene Expression Profiling Interactive Evaluation device. The evaluation of prognosis was carried out by utilizing the UALCAN, Gene Expression Profiling Interactive Evaluation (GEPIA), and DriverDBv3 databases. We additionally investigated utilizing DKK1 promoter methylation to outline most cancers sorts via the UALCAN database. In the meantime, the associated purposeful networks of DKK1 had been analyzed by utilizing the GeneMANIA interactive device and Cytoscape software program. Moreover, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway evaluation was carried out utilizing the Metascape on-line web site, and we used the cBioPotartal database to explored DKK1 expression, aberrant data, and the co-expression genes within the subgroups of lung most cancers. Lastly, we carried out the general survival (OS) meta-analysis of the DKK1 expression in lung squamous cell carcinoma (LUSC) by way of the Lung Most cancers Explorer (LCE).DKK1 was differentially expressed in several types of human cancers. DKK1 was overexpressed in human cancers together with head and neck squamous cell carcinoma (HNSC), LUSC, and pancreatic adenocarcinoma (PAAD).

Overexpression of DKK1 indicated adversarial OS in bladder urothelial carcinoma (BLCA), HNSC, and PADD, however no distinction in OS was discovered between the LUSC and wholesome teams. The excessive expression of DKK1 was additionally related to shorter disease-free survival (DFS) in HNSC, LUSC, and PAAD. Gene regulation community evaluation indicated that DKK1 was primarily concerned in Wnt signaling pathways and a number of other different signaling pathways.Our findings confirmed that DKK1 is considerably expressed in varied cancers and may very well be a biomarker for focused remedy and a predictor for prognosis of those particular cancers.
The bioinformatics evaluation revealed a big overexpression of DKK1 in HNSC, LUSC, and PAAD, with DKK1 overexpression being related to adversarial end result in these sufferers, however how DKK1 expression ranges relate to hematological malignancies and prognosis remains to be unclear. These new insights into the perform of DKK1 could present a foundation for brand new focused drug remedy and an avenue for additional investigation into the mechanisms underlying carcinogenesis of DKK1 in several most cancers sorts.Discovery of novel isoliquiritigenin analogue ISL-17 as a potential anti-gastric cancer agent

Genetic and structural research of RABL3 reveal a vital function in lymphoid growth and performance.

The small GTPase RABL3 is an oncogene of unknown physiological perform. Homozygous knockout alleles of mouse Rabl3 had been embryonic deadly, however a viable hypomorphic allele (xiamen [xm]) inflicting in-frame deletion of 4 amino acids from the interswitch area resulted in profound defects in lymphopoiesis. Impaired lymphoid progenitor growth led to deficiencies of B cells, T cells, and pure killer (NK) cells in Rabl3xm/xm mice. T cells and NK cells exhibited impaired cytolytic exercise, and mice contaminated with mouse cytomegalovirus (MCMV) displayed elevated titers within the spleen.
Myeloid cells had been regular in quantity and performance. Biophysical and crystallographic research demonstrated that RABL3 fashioned a homodimer in resolution by way of interactions between the effector binding surfaces on every subunit; monomers adopted a typical small G protein fold. RABL3xm displayed a big compensatory alteration in swap I, which adopted a β-strand configuration usually supplied by the deleted interswitch residues, thereby allowing homodimer formation.

Recombinant Coiled Coil Domain Containing Protein 60 (CCDC60)
4-RPU807Ra01
  • EUR 571.58
  • EUR 276.00
  • EUR 1813.44
  • EUR 684.48
  • EUR 1248.96
  • EUR 458.40
  • EUR 4353.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Coiled Coil Domain Containing Protein 60 expressed in: E.coli

Coiled Coil Domain Containing Protein 60 (CCDC60) Antibody (Biotin)
20-abx272905
  • EUR 560.40
  • EUR 292.80
  • EUR 1612.80
  • EUR 760.80
  • EUR 410.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Coiled Coil Domain Containing Protein 60 (CCDC60) Antibody (Biotin)
20-abx273385
  • EUR 577.20
  • EUR 292.80
  • EUR 1696.80
  • EUR 794.40
  • EUR 427.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Coiled Coil Domain Containing Protein 60 (CCDC60) Protein
20-abx166165
  • EUR 844.80
  • EUR 343.20
  • EUR 2598.00
  • EUR 994.80
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Coiled Coil Domain Containing Protein 60 (CCDC60) Protein
20-abx065993
  • EUR 910.80
  • EUR 360.00
  • EUR 2865.60
  • EUR 1095.60
  • EUR 644.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Rat Coiled Coil Domain Containing Protein 60 (CCDC60) Protein
20-abx065994
  • EUR 794.40
  • EUR 326.40
  • EUR 2448.00
  • EUR 944.40
  • EUR 577.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Coiled Coil Domain Containing Protein 60 (CCDC60) Monoclonal Antibody (Rat)
4-MAU807Ra21
  • EUR 340.80
  • EUR 3708.00
  • EUR 908.40
  • EUR 434.40
  • EUR 274.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60)

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Human)
4-PAU807Hu01
  • EUR 313.20
  • EUR 3280.80
  • EUR 811.20
  • EUR 396.00
  • EUR 264.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Coiled Coil Domain Containing Protein 60 (CCDC60)

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Mouse)
4-PAU807Mu01
  • EUR 319.20
  • EUR 3375.60
  • EUR 832.80
  • EUR 404.40
  • EUR 266.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Coiled Coil Domain Containing Protein 60 (CCDC60)

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Rat)
4-PAU807Ra01
  • EUR 330.00
  • EUR 3549.60
  • EUR 872.40
  • EUR 420.00
  • EUR 271.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60)

Goat Coiled coil domain containing protein 60(CCDC60) ELISA kit
E06C1090-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat Coiled coil domain containing protein 60(CCDC60) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Coiled coil domain containing protein 60(CCDC60) ELISA kit
E06C1090-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat Coiled coil domain containing protein 60(CCDC60) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Coiled coil domain containing protein 60(CCDC60) ELISA kit
E06C1090-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat Coiled coil domain containing protein 60(CCDC60) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Coiled coil domain containing protein 60(CCDC60) ELISA kit
E04C1090-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit Coiled coil domain containing protein 60(CCDC60) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Coiled coil domain containing protein 60(CCDC60) ELISA kit
E04C1090-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit Coiled coil domain containing protein 60(CCDC60) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Coiled coil domain containing protein 60(CCDC60) ELISA kit
E04C1090-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit Coiled coil domain containing protein 60(CCDC60) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Coiled coil domain containing protein 60(CCDC60) ELISA kit
E07C1090-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Coiled coil domain containing protein 60(CCDC60) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Coiled coil domain containing protein 60(CCDC60) ELISA kit
E07C1090-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Coiled coil domain containing protein 60(CCDC60) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Coiled coil domain containing protein 60(CCDC60) ELISA kit
E07C1090-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Coiled coil domain containing protein 60(CCDC60) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Coiled coil domain containing protein 60(CCDC60) ELISA kit
E08C1090-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Coiled coil domain containing protein 60(CCDC60) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Coiled coil domain containing protein 60(CCDC60) ELISA kit
E08C1090-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Coiled coil domain containing protein 60(CCDC60) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Coiled coil domain containing protein 60(CCDC60) ELISA kit
E08C1090-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Coiled coil domain containing protein 60(CCDC60) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Coiled coil domain containing protein 60(CCDC60) ELISA kit
E09C1090-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey Coiled coil domain containing protein 60(CCDC60) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Coiled coil domain containing protein 60(CCDC60) ELISA kit
E09C1090-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey Coiled coil domain containing protein 60(CCDC60) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Coiled coil domain containing protein 60(CCDC60) ELISA kit
E09C1090-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey Coiled coil domain containing protein 60(CCDC60) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Coiled coil domain containing protein 60(CCDC60) ELISA kit
E02C1090-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Coiled coil domain containing protein 60(CCDC60) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Coiled coil domain containing protein 60(CCDC60) ELISA kit
E02C1090-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Coiled coil domain containing protein 60(CCDC60) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Coiled coil domain containing protein 60(CCDC60) ELISA kit
E02C1090-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Coiled coil domain containing protein 60(CCDC60) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Coiled coil domain containing protein 60(CCDC60) ELISA kit
E01C1090-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Coiled coil domain containing protein 60(CCDC60) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Coiled coil domain containing protein 60(CCDC60) ELISA kit
E01C1090-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Coiled coil domain containing protein 60(CCDC60) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Coiled coil domain containing protein 60(CCDC60) ELISA kit
E01C1090-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Coiled coil domain containing protein 60(CCDC60) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Coiled coil domain containing protein 60(CCDC60) ELISA kit
E03C1090-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Coiled coil domain containing protein 60(CCDC60) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Coiled coil domain containing protein 60(CCDC60) ELISA kit
E03C1090-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Coiled coil domain containing protein 60(CCDC60) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Coiled coil domain containing protein 60(CCDC60) ELISA kit
E03C1090-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Coiled coil domain containing protein 60(CCDC60) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Coiled Coil Domain Containing Protein 60 (CCDC60) Monoclonal Antibody (Rat), APC
4-MAU807Ra21-APC
  • EUR 481.20
  • EUR 4880.40
  • EUR 1332.00
  • EUR 622.80
  • EUR 290.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with APC.

Coiled Coil Domain Containing Protein 60 (CCDC60) Monoclonal Antibody (Rat), Biotinylated
4-MAU807Ra21-Biotin
  • EUR 422.40
  • EUR 3648.00
  • EUR 1046.40
  • EUR 526.80
  • EUR 283.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with Biotin.

Coiled Coil Domain Containing Protein 60 (CCDC60) Monoclonal Antibody (Rat), Cy3
4-MAU807Ra21-Cy3
  • EUR 591.60
  • EUR 6457.20
  • EUR 1726.80
  • EUR 780.00
  • EUR 338.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with Cy3.

Coiled Coil Domain Containing Protein 60 (CCDC60) Monoclonal Antibody (Rat), FITC
4-MAU807Ra21-FITC
  • EUR 409.20
  • EUR 3927.60
  • EUR 1089.60
  • EUR 522.00
  • EUR 256.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with FITC.

Coiled Coil Domain Containing Protein 60 (CCDC60) Monoclonal Antibody (Rat), HRP
4-MAU807Ra21-HRP
  • EUR 436.80
  • EUR 4249.20
  • EUR 1174.80
  • EUR 559.20
  • EUR 272.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with HRP.

Coiled Coil Domain Containing Protein 60 (CCDC60) Monoclonal Antibody (Rat), PE
4-MAU807Ra21-PE
  • EUR 409.20
  • EUR 3927.60
  • EUR 1089.60
  • EUR 522.00
  • EUR 256.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with PE.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Human), APC
4-PAU807Hu01-APC
  • EUR 440.40
  • EUR 4297.20
  • EUR 1186.80
  • EUR 564.00
  • EUR 273.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with APC.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Human), Biotinylated
4-PAU807Hu01-Biotin
  • EUR 392.40
  • EUR 3220.80
  • EUR 939.60
  • EUR 483.60
  • EUR 270.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with Biotin.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Human), Cy3
4-PAU807Hu01-Cy3
  • EUR 536.40
  • EUR 5679.60
  • EUR 1532.40
  • EUR 702.00
  • EUR 315.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with Cy3.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Human), FITC
4-PAU807Hu01-FITC
  • EUR 375.60
  • EUR 3460.80
  • EUR 973.20
  • EUR 475.20
  • EUR 242.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with FITC.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Human), HRP
4-PAU807Hu01-HRP
  • EUR 400.80
  • EUR 3744.00
  • EUR 1047.60
  • EUR 508.80
  • EUR 256.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with HRP.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Human), PE
4-PAU807Hu01-PE
  • EUR 375.60
  • EUR 3460.80
  • EUR 973.20
  • EUR 475.20
  • EUR 242.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with PE.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Mouse), APC
4-PAU807Mu01-APC
  • EUR 448.80
  • EUR 4426.80
  • EUR 1219.20
  • EUR 577.20
  • EUR 278.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with APC.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Mouse), Biotinylated
4-PAU807Mu01-Biotin
  • EUR 398.40
  • EUR 3315.60
  • EUR 963.60
  • EUR 493.20
  • EUR 273.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with Biotin.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Mouse), Cy3
4-PAU807Mu01-Cy3
  • EUR 548.40
  • EUR 5852.40
  • EUR 1575.60
  • EUR 720.00
  • EUR 320.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with Cy3.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Mouse), FITC
4-PAU807Mu01-FITC
  • EUR 382.80
  • EUR 3565.20
  • EUR 998.40
  • EUR 486.00
  • EUR 246.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with FITC.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Mouse), HRP
4-PAU807Mu01-HRP
  • EUR 409.20
  • EUR 3855.60
  • EUR 1076.40
  • EUR 519.60
  • EUR 260.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with HRP.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Mouse), PE
4-PAU807Mu01-PE
  • EUR 382.80
  • EUR 3565.20
  • EUR 998.40
  • EUR 486.00
  • EUR 246.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with PE.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Rat), APC
4-PAU807Ra01-APC
  • EUR 465.60
  • EUR 4664.40
  • EUR 1278.00
  • EUR 601.20
  • EUR 284.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with APC.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Rat), Biotinylated
4-PAU807Ra01-Biotin
  • EUR 411.60
  • EUR 3489.60
  • EUR 1006.80
  • EUR 510.00
  • EUR 278.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with Biotin.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Rat), Cy3
4-PAU807Ra01-Cy3
  • EUR 571.20
  • EUR 6169.20
  • EUR 1654.80
  • EUR 751.20
  • EUR 330.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with Cy3.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Rat), FITC
4-PAU807Ra01-FITC
  • EUR 396.00
  • EUR 3754.80
  • EUR 1046.40
  • EUR 504.00
  • EUR 252.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with FITC.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Rat), HRP
4-PAU807Ra01-HRP
  • EUR 423.60
  • EUR 4062.00
  • EUR 1128.00
  • EUR 541.20
  • EUR 266.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with HRP.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Rat), PE
4-PAU807Ra01-PE
  • EUR 396.00
  • EUR 3754.80
  • EUR 1046.40
  • EUR 504.00
  • EUR 252.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with PE.

Anti-Coiled-coil domain-containing protein 106 Antibody
A15044 100ul
EUR 476.4
Description: Rabbit Polyclonal Coiled-coil domain-containing protein 106 Antibody. Validated in WB and tested in Human.

coiled-coil domain containing 102B antibody
23151-100ul 100ul
EUR 468

Guinea pig Coiled coil domain containing protein 60(CCDC60) ELISA kit
E05C1090-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig Coiled coil domain containing protein 60(CCDC60) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Coiled coil domain containing protein 60(CCDC60) ELISA kit
E05C1090-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig Coiled coil domain containing protein 60(CCDC60) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Coiled coil domain containing protein 60(CCDC60) ELISA kit
E05C1090-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig Coiled coil domain containing protein 60(CCDC60) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Coiled-Coil Domain Containing 90B Protein
20-abx263356
  • EUR 1930.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 10 ug
  • 2 µg

Coiled-Coil Domain Containing 69 Protein
20-abx263410
  • EUR 1930.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 10 ug
  • 2 µg

Coiled-Coil Domain Containing 25 Protein
20-abx261145
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Coiled-Coil Domain Containing 104 Protein
20-abx261181
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Coiled-Coil Domain Containing 101 Protein
20-abx262504
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Coiled-Coil Domain Containing 43 Protein
20-abx262600
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Coiled Coil Domain Containing Protein 60 (CCDC60) Monoclonal Antibody (Rat), APC-Cy7
4-MAU807Ra21-APC-Cy7
  • EUR 818.40
  • EUR 9616.80
  • EUR 2521.20
  • EUR 1101.60
  • EUR 438.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with APC-Cy7.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Human), APC-Cy7
4-PAU807Hu01-APC-Cy7
  • EUR 736.80
  • EUR 8450.40
  • EUR 2229.60
  • EUR 985.20
  • EUR 404.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with APC-Cy7.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Mouse), APC-Cy7
4-PAU807Mu01-APC-Cy7
  • EUR 753.60
  • EUR 8709.60
  • EUR 2294.40
  • EUR 1010.40
  • EUR 412.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with APC-Cy7.

Coiled Coil Domain Containing Protein 60 (CCDC60) Polyclonal Antibody (Rat), APC-Cy7
4-PAU807Ra01-APC-Cy7
  • EUR 788.40
  • EUR 9184.80
  • EUR 2413.20
  • EUR 1058.40
  • EUR 426.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Coiled Coil Domain Containing Protein 60 (CCDC60). This antibody is labeled with APC-Cy7.

Coiled-coil domain-containing protein 106 Antibody
21412-100ul 100ul
EUR 302.4

Coiled-coil domain-containing protein 106 Antibody
21412-50ul 50ul
EUR 224.4

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 7 Protein
20-abx263438
  • EUR 1930.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 10 ug
  • 2 µg

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 3 Protein
20-abx263449
  • EUR 1930.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 10 ug
  • 2 µg

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing Protein 2 (CHCHD2) Antibody
20-abx123502
  • EUR 493.20
  • EUR 710.40
  • 100 ul
  • 200 ul

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing Protein 1 (CHCHD1) Antibody
20-abx111740
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing Protein 2 (CHCHD2) Antibody
20-abx111741
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing Protein 7 (CHCHD7) Antibody
20-abx111744
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 8 (CHCH8) Antibody
abx029782-400ul 400 ul
EUR 627.6

Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 8 (CHCH8) Antibody
abx029782-80l 80 µl
EUR 343.2

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing Protein 2 (CHCHD2) Antibody
abx025575-400ul 400 ul
EUR 627.6

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing Protein 2 (CHCHD2) Antibody
abx025575-80l 80 µl
EUR 343.2

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing Protein 1 (CHCHD1) Antibody
abx340147-100ug 100 ug
EUR 469.2

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing Protein 1 (CHCHD1) Antibody
abx231633-100ug 100 ug
EUR 610.8

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing Protein 2 (CHCHD2) Antibody
abx231635-100ug 100 ug
EUR 610.8

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing Protein 7 (CHCHD7) Antibody
abx231639-100ug 100 ug
EUR 610.8

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 6 (CHCHD6) Antibody
20-abx002540
  • EUR 493.20
  • EUR 710.40
  • 100 ul
  • 200 ul

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4) Antibody
20-abx123495
  • EUR 493.20
  • EUR 710.40
  • 100 ul
  • 200 ul

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 3 (CHCHD3) Antibody
20-abx123560
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4) Antibody
20-abx109327
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (Chchd4) Antibody
20-abx111742
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 6 (CHCHD6) Antibody
20-abx111743
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 10 (CHCHD10) Antibody
abx028724-400ul 400 ul
EUR 627.6

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 10 (CHCHD10) Antibody
abx028724-80l 80 µl
EUR 343.2

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 6 (CHCHD6) Antibody
abx029848-400ul 400 ul
EUR 627.6

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 6 (CHCHD6) Antibody
abx029848-80l 80 µl
EUR 343.2

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 3 (CHCHD3) Antibody
20-abx322584
  • EUR 526.80
  • EUR 393.60
  • 100 ul
  • 50 ul

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 3 (CHCHD3) Antibody
20-abx322585
  • EUR 526.80
  • EUR 393.60
  • 100 ul
  • 50 ul

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 3 (CHCHD3) Antibody
abx431889-200ul 200 ul
EUR 460.8

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 3 (CHCHD3) Antibody
abx432065-200ul 200 ul
EUR 460.8

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 3 (CHCHD3) Antibody
abx340011-100ug 100 ug
EUR 469.2

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 10 (CHCHD10) Antibody
abx231634-100ug 100 ug
EUR 577.2

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 3 (CHCHD3) Antibody
abx231636-100ug 100 ug
EUR 610.8

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4) Antibody
abx231637-100ug 100 ug
EUR 577.2

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 6 (CHCHD6) Antibody
abx231638-100ug 100 ug
EUR 577.2

Coiled-Coil Domain Containing 8 (CCDC8) Antibody
20-abx148985
  • EUR 510.00
  • EUR 410.40
  • 100 ug
  • 50 ug

Coiled-Coil Domain Containing 102B (CCDC102B) Antibody
20-abx133928
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Coiled-Coil Domain Containing 83 (CCDC83) Antibody
abx146239-100ug 100 ug
EUR 469.2

Coiled-Coil Domain Containing 84 (CCDC84) Antibody
abx146246-100ug 100 ug
EUR 469.2

Coiled-Coil Domain Containing 134 (CCDC134) Antibody
abx146249-100ug 100 ug
EUR 469.2

Coiled-Coil Domain Containing 87 (CCDC87) Antibody
abx146265-100ug 100 ug
EUR 469.2

Coiled-Coil Domain Containing 25 (CCDC25) Antibody
abx146270-100ug 100 ug
EUR 469.2

Coiled-Coil Domain Containing 36 (CCDC36) Antibody
abx146272-100ug 100 ug
EUR 469.2

Coiled-Coil Domain Containing 57 (CCDC57) Antibody
abx146274-100ug 100 ug
EUR 469.2

Coiled-Coil Domain Containing 120 (CCDC120) Antibody
abx146278-100ug 100 ug
EUR 469.2

Coiled-Coil Domain Containing 116 (CCDC116) Antibody
abx146279-100ug 100 ug
EUR 469.2

Coiled-Coil Domain Containing 103 (CCDC103) Antibody
abx146281-100ug 100 ug
EUR 469.2

Coiled-Coil Domain Containing 22 (CCDC22) Antibody
abx146283-100ug 100 ug
EUR 469.2

Coiled-Coil Domain Containing 68 (CCDC68) Antibody
abx146285-100ug 100 ug
EUR 469.2

Coiled-Coil Domain Containing 24 (CCDC24) Antibody
abx146287-100ug 100 ug
EUR 469.2

Coiled Coil Domain Containing 80 (CCDC80) Antibody
abx146297-100ug 100 ug
EUR 469.2

Coiled-Coil Domain Containing 102B (CCDC102B) Antibody
abx146305-100ug 100 ug
EUR 469.2

Coiled-Coil Domain Containing 112 (CCDC112) Antibody
abx146309-100ug 100 ug
EUR 469.2

Coiled-Coil Domain Containing 158 (CCDC158) Antibody
20-abx002585
  • EUR 493.20
  • EUR 710.40
  • 100 ul
  • 200 ul

Coiled-Coil Domain Containing 6 (CCDC6) Antibody
20-abx123834
  • EUR 493.20
  • EUR 710.40
  • 100 ul
  • 200 ul

Coiled-Coil Domain Containing 87 (Ccdc87) Antibody
20-abx125622
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Coiled-Coil Domain Containing 115 (CCDC115) Antibody
20-abx111723
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Coiled-Coil Domain Containing 153 (CCDC153) Antibody
20-abx111724
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Coiled-Coil Domain Containing 158 (CCDC158) Antibody
20-abx111725
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Coiled-Coil Domain Containing 22 (CCDC22) Antibody
20-abx111726
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul
Dysregulated effector binding as a result of conformational adjustments within the swap I-interswitch-switch II module possible underlies the xm phenotype. One such effector could also be GPR89, putatively an ion channel or G protein-coupled receptor (GPCR). RABL3, however not RABL3xm, strongly related to and stabilized GPR89, and an N-ethyl-N-nitrosourea (ENU)-induced mutation (explorer) in Gpr89 phenocopied Rabl3xm.

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