In 1932, seven burials have been found on a Texas plantation that was initially the location of a 17th-century Caddo Indian village. Of the seven excavated graves, one set of stays (an grownup male) was notably buried in a way inconsistent with conventional Caddoan burial practices and has lengthy been presupposed to be the stays of Sieur de Marle (a member of the French explorer La Salle’s final expedition). Diary accounts of La Salle’s expedition scribe report that Sieur de Marle died alongside a river close to an Indian village throughout a trek to Canada to search out assist for colonists left behind on the ill-fated Fort St. Louis. Moreover, two lead projectiles recovered from the grave have been ballistically analyzed and decided to be per ammunition utilized in 17th-century weaponry.
Within the 1980s, anthropologists requested entry to the stays for examine, however the cranium was lacking. Cranial measurements recorded in 1940 and 1962 (by two unbiased anthropologists) have been used to analyze the ancestry of this particular person; and the Giles-Elliot (G-E) discriminant perform was calculated to be 18.1, throughout the Anglo-European vary. Dietary isotope testing on non-cranial skeletal components decided that this unknown male’s weight-reduction plan was wealthy in animal/marine protein sources, which differs appreciably from Caddo Indian populations of that point interval. With a view to genetically assess this particular person’s biogeographic ancestry and to offer additional help that this particular person is of European descent, mitochondrial DNA (mtDNA) sequencing was carried out utilizing the Utilized Biosystems™ Precision ID mtDNA Entire Genome Panel. mtDNA sequencing of a number of sections from two totally different lengthy bones yielded compiled outcomes per both Haplogroup H or R, each predominantly European mtDNA haplogroups.
Additional anthropological calculations have been performed utilizing cranial measurements, FORDISC™ software program, and discriminant perform evaluation. Two-way, four-way, and multigroup discriminant perform analyses additional classify this set of unidentified stays as being White (European) in origin, with posterior chances of 0.999, 0.881 and 0.986, respectively. Mixed with historic data of Sieur de Marle’s loss of life, in addition to overlays of historic and up to date maps which exhibit that the plantation web site aligns with Joutel’s diary accounts of de Marle’s burial, these collective outcomes help that these stays are of a European male and will presumably belong to this distinguished member of La Salle’s expedition staff.
Design, Synthesis and Analysis of two,4,6-substituted Pyrimidine Derivatives as BACE-1 inhibitor: Believable lead for Alzheimer’s Illness
Alzheimer’s illness is likely one of the most typical neurodegenerative dysfunction afflicting a big mass of inhabitants. BACE-1 (β-secretase) is an aspartyl protease of the amyloidogenic pathway thought-about liable for Alzheimer’s illness (AD). Since, it catalyzes the speed limiting step of Aβ-42 manufacturing from amyloid precursor protein (APP),its inhibition is taken into account a viable therapeutic technique. We’ve reported the design of small molecular weight compounds speculated to be blood mind permeable as BACE-1 inhibitors. The clue for the design of this sequence is drawn from the beforehand designed sequence from our analysis group.Design and synthesis of two,4,6-substituted pyrimidine derivatives has been reported. In vitro FRET primarily based screening of synthesized derivatives was carried out to guage the BACE-1 inhibition profile.
Primarily based on the docking simulation research, a library of derivatives was designed, synthesized and evaluated for BACE-1 inhibition in-vitro. The docking research have been carried out on Glide (Schrodinger suite) and Molegro digital docker. Theoretical toxicity was predicted utilizing Osiris Property Explorer. The synthesized compounds have been examined for BACE-1 inhibition utilizing in vitro assay primarily based on Fluorescence Resonance Power Switch approach. The % inhibition was calculated as a measure of exercise.
The designed compounds revealed robust interactions with the specified amino acids of BACE-1 lively websites. The fragrant rings positioned at fourth and sixth place of pyrimidine ring occupied S1 and S3 substrate binding clefts whereas the amino group fashioned hydrogen bonding interactions with Asp32 and Asp228. In silico information ensured that the compounds have been orally bioavailable and mind permeable. The in vitro testing confirmed that the compounds inhibited BACE-1 at 10µM focus.
Compounds substituted with m-benzyloxy on one fragrant ring and o,p-di-chloro on one other fragrant ring displayed most BACE-1 inhibition. Compound 2.13A displayed excessive docking rating and was discovered to be most potent with IC50 of 6.92µM. The sequence displayed correlation between docking rating and BACE-1 inhibition profile.
PAWER: protein array internet exploreR
Protein microarray is a well-established strategy for characterizing exercise ranges of 1000’s of proteins in a parallel method. Evaluation of protein microarray information is advanced and time-consuming, whereas present options are both outdated or difficult to make use of with out programming expertise. The standard information evaluation pipeline consists of a knowledge preprocessing step, adopted by differential expression evaluation, which is then put into context by way of purposeful enrichment. Usually, biologists would wish to assemble their very own workflow by combining a set of unrelated instruments to investigate experimental information. Supplied that the majority of those instruments are developed independently by varied bioinformatics teams, making them work collectively might be an actual problem.
Recombinant Human ApoE4 Protein |
PROTP02649-4 |
BosterBio |
500ug |
EUR 380.4 |
Description: ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Individuals heterozygous for the ApoE4 allele are at higher risk of late-onset Alzheimer’s disease. Recombinant human ApoE4 is a 34.4 kDa protein containing 300 amino acid residues. |
Human ApoE4 Recombinant Protein |
100-126 |
ReliaTech |
500 µg |
EUR 196.35 |
Description: ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Individuals heterozygous for the ApoE4 allele are at higher risk of late-onset Alzheimer’s disease. Recombinant human ApoE4 is a 34.4 kDa protein containing 300 amino acid residues. |
Human ApoE4 Recombinant Protein |
100-126S |
ReliaTech |
100 µg |
EUR 92.4 |
Description: ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Individuals heterozygous for the ApoE4 allele are at higher risk of late-onset Alzheimer’s disease. Recombinant human ApoE4 is a 34.4 kDa protein containing 300 amino acid residues. |
Human ApoE4 Recombinant Protein Lyophilized |
IHUAPOE4RLY100UG |
Innovative research |
each |
EUR 341 |
|
Description: Human ApoE4 Recombinant Protein Lyophilized |
Human ApoE4 Recombinant Protein Lyophilized |
MBS8431232-INQUIRE |
MyBiosource |
INQUIRE |
Ask for price |
Recombinant Human APOE4 Protein, His, E.coli-1mg |
QP11051-1mg |
EnQuireBio |
1mg |
EUR 458.4 |
Recombinant Human APOE4 Protein, His, E.coli-100ug |
QP11051-100ug |
EnQuireBio |
100ug |
EUR 186 |
Recombinant Human APOE4 Protein, His, E.coli-500ug |
QP11051-500ug |
EnQuireBio |
500ug |
EUR 284.4 |
APOE4 Apolipoprotein E4 Human Recombinant Protein |
PROTP02649-1 |
BosterBio |
Regular: 500ug |
EUR 402 |
Description: Apolipoprotein E4 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing a total of 306 amino acids including a His Tag at N-terminus and having a molecular mass of 35.2kDa. The Accession # is P02649 VAR_000652. |
Human ApoE4 |
MBS691668-5x05mg |
MyBiosource |
5x0.5mg |
EUR 1725 |
ApoE4 antibody |
70R-12420 |
Fitzgerald |
100 ug |
EUR 385 |
|
Description: Rabbit polyclonal ApoE4 antibody |
ApoE4 Antibody |
5699-100 |
Biovision |
each |
EUR 398.4 |
ApoE4 Antibody |
5699-30T |
Biovision |
each |
EUR 175.2 |
Human Apolipoprotein E / APOE4 Protein, His Tag (MALS verified) |
APE-H52H9 |
ACROBIOSYSTEMS |
100ug |
EUR 2493.1 |
|
Description: Human APOE4, His Tag (APE-H52H9) is expressed from human 293 cells (HEK293). It contains AA Lys 19 - His 317 (Accession # P02649-1 (C130R)). |
Human Apolipoprotein E / APOE4 Protein, Tag Free (MALS verified) |
APE-H5215 |
ACROBIOSYSTEMS |
100ug |
EUR 2493.1 |
|
Description: Human APOE4 Protein, Tag Free (APE-H5215) is expressed from human 293 cells (HEK293). It contains AA Lys 19 - His 317 (Accession # P02649-1 (C130R)). |
ApoE4, human recombinant |
4699-100 |
Biovision |
each |
EUR 170.4 |
ApoE4, human recombinant |
4699-1000 |
Biovision |
each |
EUR 548.4 |
ApoE4, human recombinant |
4699-50 |
Biovision |
each |
EUR 151.2 |
ApoE4, human recombinant |
4699-500 |
Biovision |
each |
EUR 339.6 |
ApoE4, human recombinant |
4699-5000 |
Biovision |
each |
EUR 1776 |
Biotinylated Human Apolipoprotein E / APOE4 Protein, His,Avitag™ (MALS verified) |
APE-H52E7 |
ACROBIOSYSTEMS |
25ug |
EUR 1487.3 |
|
Description: Biotinylated Human APOE4 His,Avitag (APE-H52E7) is expressed from human 293 cells (HEK293). It contains AA Lys 19 - His 317 (Accession # P02649-1 (C130R)). |
ApoE4 monoclonal antibody (4E4) |
MBS566824-01mg |
MyBiosource |
0.1mg |
EUR 445 |
ApoE4 monoclonal antibody (4E4) |
MBS566824-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1955 |
Apolipoprotein E4 (APOE4) Antibody |
abx342004-100g |
Abbexa |
100 µg |
Ask for price |
Apolipoprotein E4 (APOE4) Antibody |
abx342004-20g |
Abbexa |
20 µg |
EUR 750 |
Apolipoprotein E4 (APOE4) Antibody |
abx342004-50g |
Abbexa |
50 µg |
EUR 2675 |
Human Apoprotein E4 (APOE4) ELISA Kit |
MBS3801700-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 6725 |
Human Apoprotein E4 (APOE4) ELISA Kit |
MBS3801700-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 550 |
Human Apoprotein E4 (APOE4) ELISA Kit |
MBS3801700-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 3420 |
Human Apoprotein E4 (APOE4) ELISA Kit |
MBS3801700-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 765 |
APOE4 (BSB-170), MMab, 0.1mL Concentrate |
MBS373160-01mLConcentrate |
MyBiosource |
0.1mL(Concentrate) |
EUR 290 |
APOE4 (BSB-170), MMab, 0.1mL Concentrate |
MBS373160-05mLConcentrate |
MyBiosource |
0.5mL(Concentrate) |
EUR 500 |
APOE4 (BSB-170), MMab, 0.1mL Concentrate |
MBS373160-15mLRTU |
MyBiosource |
15mL(RTU) |
EUR 605 |
APOE4 (BSB-170), MMab, 0.1mL Concentrate |
MBS373160-3mLRTU |
MyBiosource |
3mL(RTU) |
EUR 290 |
APOE4 (BSB-170), MMab, 0.1mL Concentrate |
MBS373160-7mLRTU |
MyBiosource |
7mL(RTU) |
EUR 390 |
Apolipoprotein E4, (ApoE4) (1mg) Human Recombinant |
AE-102-10 |
AlexoTech AB |
1 mg |
EUR 330 |
Human iPS Cell Line (Episomal, CD34+, ApoE4) |
iPS16 |
ALSTEM |
1 Vial |
EUR 1599.2 |
Apolipoprotein E4, (ApoE4) (1mg) 1-199 Human Recombinant |
AE-103-10 |
AlexoTech AB |
1 mg |
EUR 330 |
Apolipoprotein E4, (ApoE4) (1mg) 1-162 Human Recombinant |
AE-104-10 |
AlexoTech AB |
1 mg |
EUR 330 |
Apolipoprotein E4, (ApoE4) (1mg) 1-132 Human Recombinant |
AE-105-10 |
AlexoTech AB |
1 mg |
EUR 330 |
HighQC™ Human IPS Cell Line (Episomal, CD34+, ApoE4) |
ABC-SC2105 |
AcceGen |
1 vial |
Ask for price |
Description: Footprint-free human iPS (induced pluripotent stem) cell line was derived from human bone marrow CD34+ mononuclear cells by ectopic expression of OCT4, SOX2, KLF4, c-MYC and Lin28 genes using episomal plasmids. The cells were derived using morphological selection criteria and without the use of fluorescent marker or drug selection. When cultured under standard human ES cell culture conditions, the morphology of human iPS cells are identical to that of human ES cells. The cells also express the pluripotency markers TRA-1-60, SSEA-3 and Oct4, and demonstrate strong endogenous alkaline phosphatase activity. |
HighQC™ Human IPSC-Derived Neural Stem Cell-Alzheimer's Disease Patient (APOE4 HOM) |
ABC-SC0059T |
AcceGen |
1 vial |
Ask for price |
Description: Gentaur Human iPSC-Derived Neural Stem Cells (NSCs) are derived from integration-free, induced pluripotent stem cells (iPSCs) under fully defined neural induction conditions. The NSCs express typical markers of cerebral cortical neural stem and progenitor cells such as PAX6, FOXG1 and nestin, and spontaneously form polarized neural tube-like rosette structures when plated as a monolayer in culture (see below). Additionally, Gentaur NSCs are capable of generating a spectrum of cerebral cortical excitatory and inhibitory neurons that are electrically active and have the ability to form functional synapses and circuits in vitro. After thawing and plating, the neural stem cells terminally differentiate to acquire mature electrophysiological properties, and form functional synaptic networks over a period of 40 ~ 50 days.Gentaur NSCs are easy to differentiate to neurons or mixed neural cell types, following our protocols and using our tailored media and reagent bundles. A highly pure population of neurons can be generated from Gentaur NSCs following the synchronous differentiation protocol. Using our specialized coating reagents, neurons derived from Gentaur NSCs can be maintained in culture long-term (andgt;1 year). NSCs are available from multiple donors to suit your research needs and have been characterized extensively. |
ApoE3 protein |
30R-2381 |
Fitzgerald |
1 mg |
EUR 126 |
|
Description: Purified recombinant Human ApoE3 protein |
ApoE2 protein |
30R-2387 |
Fitzgerald |
1 mg |
EUR 150 |
|
Description: Purified recombinant Human ApoE2 protein |
ApoE3 protein |
30R-AA016 |
Fitzgerald |
500 ug |
EUR 312 |
|
Description: Purified recombinant Human ApoE3 protein |
ApoE2 protein |
30R-AA019 |
Fitzgerald |
500 ug |
EUR 312 |
|
Description: Purified recombinant Human ApoE2 protein |
ApoE3 protein |
MBS538089-5x05mg |
MyBiosource |
5x0.5mg |
EUR 1945 |
ApoE2 protein |
MBS538318-5x05mg |
MyBiosource |
5x0.5mg |
EUR 1945 |
Recombinant Human ApoE2 Protein |
PROTP02649-2 |
BosterBio |
500ug |
EUR 380.4 |
Description: ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. It’s interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Compared with E3 and E4, E2 exhibits the lowest receptor binding affinity. E2 allele carriers had significantly lower levels of total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol, as well as increased ApoE levels. Recombinant human ApoE2 is a 34.3 kDa protein containing 300 amino acid residues. |
Recombinant Human ApoE3 Protein |
PROTP02649-3 |
BosterBio |
500ug |
EUR 380.4 |
Description: ApoE3 belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. E3 is the most common isoform and is present in 40-90% of the population. Recombinant human ApoE3 is a 34.0 kDa protein containing 299 amino acid residues. |
Purified recombinant Human ApoE2 protein |
MBS5308520-05mg |
MyBiosource |
0.5mg |
EUR 480 |
Purified recombinant Human ApoE2 protein |
MBS5308520-5x05mg |
MyBiosource |
5x0.5mg |
EUR 2010 |
Purified recombinant Human ApoE3 protein |
MBS5308521-01mg |
MyBiosource |
0.1mg |
EUR 255 |
Purified recombinant Human ApoE3 protein |
MBS5308521-5x01mg |
MyBiosource |
5x0.1mg |
EUR 990 |
ApoE3 Recombinant Protein |
40-136-01mg |
ProSci |
0.1 mg |
EUR 311.1 |
Description: ApoE3 belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. E3 is the most common isoform and is present in 40-90% of the population. Recombinant human ApoE3 is a 34.4 kDa protein containing 300 amino acid residues. |
ApoE3 Recombinant Protein |
40-136-05mg |
ProSci |
0.5 mg |
EUR 437.1 |
Description: ApoE3 belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. E3 is the most common isoform and is present in 40-90% of the population. Recombinant human ApoE3 is a 34.4 kDa protein containing 300 amino acid residues. |
ApoE2 Recombinant Protein |
40-140-01mg |
ProSci |
0.1 mg |
EUR 311.1 |
Description: ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. It’s interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Compared with E3 and E4, E2 exhibits the lowest receptor binding affinity. E2 allele carriers had significantly lower levels of total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol, as well as increased ApoE levels. Recombinant human ApoE2 is a 34.3 kDa protein containing 300 amino acid residues. |
ApoE2 Recombinant Protein |
40-140-05mg |
ProSci |
0.5 mg |
EUR 437.1 |
Description: ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. It’s interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Compared with E3 and E4, E2 exhibits the lowest receptor binding affinity. E2 allele carriers had significantly lower levels of total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol, as well as increased ApoE levels. Recombinant human ApoE2 is a 34.3 kDa protein containing 300 amino acid residues. |
Human Apolipoprotein E / APOE3 Protein, His Tag |
APE-H5246 |
ACROBIOSYSTEMS |
100ug |
EUR 2471.7 |
|
Description: Human APOE3, His Tag (APE-H5246) is expressed from human 293 cells (HEK293). It contains AA Lys 19 - His 317 (Accession # P02649-1). |
ApoE protein |
30-1053 |
Fitzgerald |
50 ug |
EUR 1162 |
|
Description: Purified native Human ApoE protein |
ApoE protein |
30-AA30 |
Fitzgerald |
100 ug |
EUR 445 |
|
Description: Purified native Human ApoE protein |
ApoE protein |
MBS5303616-005mg |
MyBiosource |
0.05mg |
EUR 1960 |
ApoE protein |
MBS5303616-5x005mg |
MyBiosource |
5x0.05mg |
EUR 8600 |
ApoE protein |
MBS537055-INQUIRE |
MyBiosource |
INQUIRE |
Ask for price |
Rabbit Anti-Human ApoE3 protein antiserum #1 |
APOE31-S |
Alpha Diagnostics |
100 ul |
EUR 548.4 |
Recombinant Human APOE3 Protein, His, E.coli-1mg |
QP10522-1mg |
EnQuireBio |
1mg |
EUR 381.6 |
Recombinant Human APOE3 Protein, His, E.coli-100ug |
QP10522-100ug |
EnQuireBio |
100ug |
EUR 186 |
Recombinant Human APOE3 Protein, His, E.coli-500ug |
QP10522-500ug |
EnQuireBio |
500ug |
EUR 241.2 |
Human ApoE2 Recombinant Protein |
100-124 |
ReliaTech |
500 µg |
EUR 196.35 |
Description: ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. Its interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Compared with E3 and E4, E2 exhibits the lowest receptor binding affinity. E2 allele carriers had significantly lower levels of total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol, as well as increased ApoE levels. Recombinant human ApoE2 is a 34.3 kDa protein containing 300 amino acid residues. |
Human ApoE2 Recombinant Protein |
100-124S |
ReliaTech |
100 µg |
EUR 92.4 |
Description: ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. Its interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Compared with E3 and E4, E2 exhibits the lowest receptor binding affinity. E2 allele carriers had significantly lower levels of total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol, as well as increased ApoE levels. Recombinant human ApoE2 is a 34.3 kDa protein containing 300 amino acid residues. |
Human ApoE3 Recombinant Protein |
100-125 |
ReliaTech |
500 µg |
EUR 196.35 |
Description: ApoE3 belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solubilization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. E3 is the most common isoform and is present in 40-90% of the population. Recombinant human ApoE3 is a 34.0 kDa protein containing 300 amino acid residues. |
Human ApoE3 Recombinant Protein |
100-125S |
ReliaTech |
100 µg |
EUR 92.4 |
Description: ApoE3 belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solubilization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. E3 is the most common isoform and is present in 40-90% of the population. Recombinant human ApoE3 is a 34.0 kDa protein containing 300 amino acid residues. |
Human Apolipoprotein E / APOE2 Protein, His Tag (SPR verified) |
APE-H52H6 |
ACROBIOSYSTEMS |
100ug |
EUR 2140 |
|
Description: Human APOE2, His Tag (APE-H52H6) is expressed from human 293 cells (HEK293). It contains AA Lys 19 - His 317 (Accession # P02649-1 (R176C)). |
Human Apolipoprotein E / APOE3 Protein, Tag Free (MALS verified) |
APE-H5213 |
ACROBIOSYSTEMS |
1mg |
EUR 2471.7 |
|
Description: Human APOE3 Protein, Tag Free (APE-H5213) is expressed from human 293 cells (HEK293). It contains AA Lys 19 - His 317 (Accession # P02649-1). |
Human Apolipoprotein E / APOE3 Protein, Tag Free (MALS verified) |
APE-H5216 |
ACROBIOSYSTEMS |
100ug |
EUR 2471.7 |
|
Description: Human APOE3 Protein, Tag Free (APE-H5216) is expressed from human 293 cells (HEK293). It contains AA Lys 19 - His 317 (Accession # P02649-1 ). |
Human APOE Protein Lysate |
MBS137389-002mg |
MyBiosource |
0.02mg |
EUR 365 |
Human APOE Protein Lysate |
MBS137389-5x002mg |
MyBiosource |
5x0.02mg |
EUR 1410 |
Human ApoE2 Recombinant Protein Lyophilized |
IHUAPOE2RLY100UG |
Innovative research |
each |
EUR 341 |
|
Description: Human ApoE2 Recombinant Protein Lyophilized |
Human ApoE3 Recombinant Protein Lyophilized |
IHUAPOE3RLY100UG |
Innovative research |
each |
EUR 341 |
|
Description: Human ApoE3 Recombinant Protein Lyophilized |
Human ApoE2 Recombinant Protein Lyophilized |
MBS8431230-INQUIRE |
MyBiosource |
INQUIRE |
Ask for price |
Human ApoE3 Recombinant Protein Lyophilized |
MBS8431231-INQUIRE |
MyBiosource |
INQUIRE |
Ask for price |
Human Apolipoprotein E / APOE2 (R154S) Protein, His Tag |
APE-H5256 |
ACROBIOSYSTEMS |
100ug |
EUR 2749.9 |
|
Description: Human APOE2 (R154S), His Tag (APE-H5256) is expressed from human 293 cells (HEK293). It contains AA Lys 19 - His 317 (Accession # P02649-1 (R154S)). |
APOE3 Apolipoprotein E3 Human Recombinant Protein |
PROTP02649 |
BosterBio |
Regular: 500ug |
EUR 380.4 |
Description: APOE3 Human Recombinant (19-317) produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 306 amino acids and having a molecular mass of 35kDa.;The APOE is fused to a 7 amino acid His tag [M-HHHHHH] at N-terminus and purified by proprietary chromatographic techniques. |
Human APOE Protein Lysate 20ug |
IHUAPOEPLLY20UG |
Innovative research |
each |
EUR 213 |
|
Description: Human APOE Protein Lysate 20ug |
Biotinylated Human Apolipoprotein E / APOE3 Protein, His,Avitag™ (MALS verified) |
APE-H52E3 |
ACROBIOSYSTEMS |
25ug |
EUR 1487.3 |
|
Description: Biotinylated Human APOE3, His,Avitag (APE-H52E3) is expressed from human 293 cells (HEK293). It contains AA Lys 19 - His 317 (Accession # P02649-1). |
Biotinylated Human Apolipoprotein E / APOE2 Protein, His,Avitag™ (MALS verified) |
APE-H52E5 |
ACROBIOSYSTEMS |
25ug |
EUR 1487.3 |
|
Description: Biotinylated Human APOE2, His,Avitag (APE-H52E5) is expressed from human 293 cells (HEK293). It contains AA Lys 19 - His 317 (Accession # P02649-1 (R176C)). |
Rat Apolipoprotein E (APOE) Protein |
20-abx065427 |
Abbexa |
-
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-
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-
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-
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-
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|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Dog Apolipoprotein E (APOE) Protein |
20-abx168028 |
Abbexa |
-
Ask for price
-
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-
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-
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-
Ask for price
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Pig Apolipoprotein E (APOE) Protein |
20-abx652555 |
Abbexa |
-
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-
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-
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-
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-
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|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Dog Apolipoprotein E (APOE) Protein |
abx168028-1ml |
Abbexa |
1 ml |
EUR 450 |
Rat Apolipoprotein E (APOE) Protein |
abx065427-100g |
Abbexa |
100 µg |
EUR 612.5 |
Rat Apolipoprotein E (APOE) Protein |
abx065427-10g |
Abbexa |
10 µg |
EUR 237.5 |
Rat Apolipoprotein E (APOE) Protein |
abx065427-50g |
Abbexa |
50 µg |
EUR 425 |
Pig Apolipoprotein E (APOE) Protein |
abx652555-5mg |
Abbexa |
5 mg |
EUR 5300 |
Recombinant Human APOE Protein |
MBS8248560-001mg |
MyBiosource |
0.01mg |
EUR 170 |
Recombinant Human APOE Protein |
MBS8248560-005mg |
MyBiosource |
0.05mg |
EUR 270 |
Recombinant Human APOE Protein |
MBS8248560-05mg |
MyBiosource |
0.5mg |
EUR 995 |
Recombinant Human APOE Protein |
MBS8248560-5x05mg |
MyBiosource |
5x0.5mg |
EUR 4405 |
Recombinant Mouse APOE Protein |
MBS8248561-001mg |
MyBiosource |
0.01mg |
EUR 250 |
Recombinant Mouse APOE Protein |
MBS8248561-005mg |
MyBiosource |
0.05mg |
EUR 545 |
Recombinant Mouse APOE Protein |
MBS8248561-05mg |
MyBiosource |
0.5mg |
EUR 1905 |
Recombinant Mouse APOE Protein |
MBS8248561-5x05mg |
MyBiosource |
5x0.5mg |
EUR 8485 |
Recombinant Human APOE protein |
MBS1561213-005mg |
MyBiosource |
0.05mg |
EUR 320 |
Recombinant Human APOE protein |
MBS1561213-01mg |
MyBiosource |
0.1mg |
EUR 410 |
Recombinant Human APOE protein |
MBS1561213-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1520 |
Recombinant Mouse Apolipo Protein E/ApoE Protein (C-6His) |
MBS2553444-001mg |
MyBiosource |
0.01mg |
EUR 175 |
Recombinant Mouse Apolipo Protein E/ApoE Protein (C-6His) |
MBS2553444-005mg |
MyBiosource |
0.05mg |
EUR 485 |
Recombinant Mouse Apolipo Protein E/ApoE Protein (C-6His) |
MBS2553444-5x005mg |
MyBiosource |
5x0.05mg |
EUR 2165 |
Recombinant Human Apolipo Protein E/ApoE Protein (C-6His) |
MBS2552366-001mg |
MyBiosource |
0.01mg |
EUR 85 |
Recombinant Human Apolipo Protein E/ApoE Protein (C-6His) |
MBS2552366-005mg |
MyBiosource |
0.05mg |
EUR 115 |
Recombinant Human Apolipo Protein E/ApoE Protein (C-6His) |
MBS2552366-5x005mg |
MyBiosource |
5x0.05mg |
EUR 520 |
APOE Protein Vector (Rat) (pPM-C-HA) |
PV254108 |
ABM |
500 ng |
EUR 723.6 |
Mouse Apolipoprotein E (APOE) Protein |
20-abx065426 |
Abbexa |
-
Ask for price
-
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-
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-
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-
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|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Human Apolipoprotein E (APOE) Protein |
20-abx065429 |
Abbexa |
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Mouse Apolipoprotein E (APOE) Protein |
abx065426-100g |
Abbexa |
100 µg |
EUR 587.5 |
Mouse Apolipoprotein E (APOE) Protein |
abx065426-10g |
Abbexa |
10 µg |
EUR 225 |
Mouse Apolipoprotein E (APOE) Protein |
abx065426-50g |
Abbexa |
50 µg |
EUR 400 |
Human Apolipoprotein E (APOE) Protein |
abx065429-100g |
Abbexa |
100 µg |
EUR 425 |
Human Apolipoprotein E (APOE) Protein |
abx065429-10g |
Abbexa |
10 µg |
EUR 187.5 |
Human Apolipoprotein E (APOE) Protein |
abx065429-50g |
Abbexa |
50 µg |
EUR 300 |
Human Apolipoprotein E (APOE) Protein |
abx694213-10nmol |
Abbexa |
10 nmol |
EUR 600 |
Human Apolipoprotein E (APOE) Protein |
abx694213-5nmol |
Abbexa |
5 nmol |
EUR 400 |
APOE Protein Vector (Rat) (pPB-C-His) |
PV254106 |
ABM |
500 ng |
EUR 723.6 |
APOE Protein Vector (Rat) (pPB-N-His) |
PV254107 |
ABM |
500 ng |
EUR 723.6 |
APOE Protein Vector (Rat) (pPM-C-His) |
PV254109 |
ABM |
500 ng |
EUR 723.6 |
Rabbit Apolipoprotein E (APOE) Protein |
20-abx652556 |
Abbexa |
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Rabbit Apolipoprotein E (APOE) Protein |
abx652556-5mg |
Abbexa |
5 mg |
EUR 5300 |
APOE Protein Vector (Human) (pPM-C-HA) |
PV002127 |
ABM |
500 ng |
EUR 394.8 |
APOE Protein Vector (Mouse) (pPM-C-HA) |
PV155300 |
ABM |
500 ng |
EUR 723.6 |
Recombinant Mouse ApoE/APOE/Apolipoprotein E Protein |
RP00640 |
Abclonal |
10μg |
EUR 260 |
|
APOE Protein Vector (Human) (pPB-C-His) |
PV002125 |
ABM |
500 ng |
EUR 394.8 |
APOE Protein Vector (Human) (pPB-N-His) |
PV002126 |
ABM |
500 ng |
EUR 394.8 |
APOE Protein Vector (Human) (pPM-C-His) |
PV002128 |
ABM |
500 ng |
EUR 394.8 |
APOE Protein Vector (Mouse) (pPB-C-His) |
PV155298 |
ABM |
500 ng |
EUR 723.6 |
APOE Protein Vector (Mouse) (pPB-N-His) |
PV155299 |
ABM |
500 ng |
EUR 723.6 |
APOE Protein Vector (Mouse) (pPM-C-His) |
PV155301 |
ABM |
500 ng |
EUR 723.6 |
Recombinant Pig APOE protein, N-His Tag |
IMP-3575 |
Creative BioMart |
10µg |
EUR 432 |
|
Description: Recombinant Proteins |
Recombinant Dog APOE protein, N-His Tag |
IMP-3578 |
Creative BioMart |
10µg |
EUR 432 |
|
Description: Recombinant Proteins |
Recombinant Rat APOE protein, N-His Tag |
IMP-3581 |
Creative BioMart |
10µg |
EUR 432 |
|
Description: Recombinant Proteins |
Recombinant Human ApoE protein (C-6His) |
CD02311-10ug |
Jiaxing Korain Biotech Ltd (BT Labs) |
10ug |
EUR 24 |
|
Description: Recombinant Human Apolipoprotein E is produced by our Mammalian expression system and the target gene encoding Lys19-His317 is expressed with a 6His tag at the C-terminus. |
Recombinant Human ApoE protein (C-6His) |
CD02311-50ug |
Jiaxing Korain Biotech Ltd (BT Labs) |
50ug |
EUR 94 |
|
Description: Recombinant Human Apolipoprotein E is produced by our Mammalian expression system and the target gene encoding Lys19-His317 is expressed with a 6His tag at the C-terminus. |
Recombinant Mouse APOE protein (C-6His) |
CD00621-10ug |
Jiaxing Korain Biotech Ltd (BT Labs) |
10ug |
EUR 247 |
|
Description: Recombinant Mouse Apolipoprotein E is produced by our Mammalian expression system and the target gene encoding Glu19-Gln311 is expressed with a 6His tag at the C-terminus. |
Recombinant Mouse APOE protein (C-6His) |
CD00621-50ug |
Jiaxing Korain Biotech Ltd (BT Labs) |
50ug |
EUR 976 |
|
Description: Recombinant Mouse Apolipoprotein E is produced by our Mammalian expression system and the target gene encoding Glu19-Gln311 is expressed with a 6His tag at the C-terminus. |
APOE Protein Vector (Human) (pPB-His-MBP) |
PV322902 |
ABM |
500 ng |
EUR 394.8 |
APOE Protein Vector (Human) (pPB-His-GST) |
PV322903 |
ABM |
500 ng |
EUR 394.8 |
Recombinant Mouse Apoe protein, N-His Tag |
IMP-1451 |
Creative BioMart |
20µg |
EUR 720 |
|
Description: Recombinant Proteins |
Recombinant Mouse Apoe protein, N-His Tag |
IMP-1452 |
Creative BioMart |
20µg |
EUR 720 |
|
Description: Recombinant Proteins |
Recombinant Mouse Apoe protein, C-His Tag |
IMP-1455 |
Creative BioMart |
20µg |
EUR 720 |
|
Description: Recombinant Proteins |
Recombinant Human APOE protein, N-His Tag |
IMP-1727 |
Creative BioMart |
100µg |
EUR 2400 |
|
Description: Recombinant Proteins |
Recombinant Human APOE protein, N-His Tag |
IMP-3573 |
Creative BioMart |
10µg |
EUR 432 |
|
Description: Recombinant Proteins |
APOE Protein Vector (Human) (pPM-N-D-C-HA) |
PV322904 |
ABM |
500 ng |
EUR 662.4 |
Goat Anti-Human ApoE protein antiserum #1 |
APOE11-S |
Alpha Diagnostics |
100 ul |
EUR 548.4 |
Recombinant Cattle APOE protein, N-His Tag |
IMP-3580 |
Creative BioMart |
10µg |
EUR 432 |
|
Description: Recombinant Proteins |
APOE Protein Vector (Human) (pPM-N-D-C-His) |
PV322905 |
ABM |
500 ng |
EUR 662.4 |
Recombinant Rat APOE protein, N-His-GST Tag |
IMP-3576 |
Creative BioMart |
10µg |
EUR 432 |
|
Description: Recombinant Proteins |
Recombinant Human APOE Protein, His-tagged |
APOE-17H |
Creative BioMart |
50ug |
EUR 398.4 |
|
Description: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Recombinant Mouse Apoe protein, His-tagged |
Apoe-25M |
Creative BioMart |
20ug 1mg/ml |
EUR 558.4 |
|
Description: Store at -lt- -20 centigrade, stable for 6 months after receipt.Please minimize freeze-thaw cycles. |
Recombinant Human Apolipoprotein E/ApoE Protein |
RP00306 |
Abclonal |
10 μg |
EUR 130.8 |
Recombinant Human Apolipoprotein E/ApoE Protein |
MBS9144256-002mg |
MyBiosource |
0.02mg |
EUR 165 |
Recombinant Human Apolipoprotein E/ApoE Protein |
MBS9144256-005mg |
MyBiosource |
0.05mg |
EUR 195 |
Recombinant Human Apolipoprotein E/ApoE Protein |
MBS9144256-01mg |
MyBiosource |
0.1mg |
EUR 250 |
Recombinant Human Apolipoprotein E/ApoE Protein |
MBS9144256-5x01mg |
MyBiosource |
5x0.1mg |
EUR 945 |
Recombinant Human Apolipoprotein E (ApoE) Protein |
MBS286103-01mg |
MyBiosource |
0.1mg |
EUR 440 |
Recombinant Human Apolipoprotein E (ApoE) Protein |
MBS286103-05mg |
MyBiosource |
0.5mg |
EUR 1200 |
Recombinant Human Apolipoprotein E (ApoE) Protein |
MBS286103-1mg |
MyBiosource |
1mg |
EUR 1665 |
Recombinant Human Apolipoprotein E (ApoE) Protein |
MBS286103-5x1mg |
MyBiosource |
5x1mg |
EUR 7480 |
Recombinant Mouse APOE protein, N-His-GST Tag |
IMP-3574 |
Creative BioMart |
10µg |
EUR 432 |
|
Description: Recombinant Proteins |
Recombinant Rat APOE Protein, His (Fc)-Avi-tagged |
APOE-382R |
Creative BioMart |
50ug |
EUR 2398.4 |
|
Description: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles. |
Recombinant Mouse Apoe protein, N-His & C-Myc Tag |
IMP-1453 |
Creative BioMart |
20µg |
EUR 720 |
|
Description: Recombinant Proteins |
Recombinant Mouse Apoe protein, N-His & C-Myc Tag |
IMP-1454 |
Creative BioMart |
20µg |
EUR 720 |
|
Description: Recombinant Proteins |
Recombinant Human ApoE protein W. Blot +ve control |
APOE11-C |
Alpha Diagnostics |
100 ul |
EUR 343.2 |
Recombinant Human ApoE protein W. Blot +ve control |
APOE12-C |
Alpha Diagnostics |
100 ul |
EUR 343.2 |
Recombinant Rabbit APOE protein, N-His & C-Myc Tag |
IMP-1448 |
Creative BioMart |
20µg |
EUR 720 |
|
Description: Recombinant Proteins |
Recombinant Human APOE Protein, His (Fc)-Avi-tagged |
APOE-364H |
Creative BioMart |
50ug |
EUR 2398.4 |
|
Description: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles. |
Recombinant Mouse APOE Protein, His (Fc)-Avi-tagged |
APOE-638M |
Creative BioMart |
50ug |
EUR 2398.4 |
|
Description: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles. |
APOE Recombinant Protein (Rat) |
RP190577 |
ABM |
100 ug |
Ask for price |
Biotinylated Human Apolipoprotein E / APOE3 (R154S) Protein, His,Avitag™ (MALS verified) |
APE-H52E4 |
ACROBIOSYSTEMS |
25ug |
EUR 1487.3 |
|
Description: Biotinylated Human APOE3 (R154S), His,Avitag (APE-H52E4) is expressed from human 293 cells (HEK293). It contains AA Lys 19 - His 317 (Accession # P02649-1 (R154S)). |
Recombinant Human ApolipoProtein E/APOE Protein, His Tag |
E40KMH686 |
EnoGene |
20ug |
EUR 495 |
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