Mitochondrial DNA analysis of the putative skeletal remains of Sieur de Marle: Genetic support for anthropological assessment of biogeographic ancestry

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Mitochondrial DNA analysis of the putative skeletal remains of Sieur de Marle: Genetic support for anthropological assessment of biogeographic ancestry

In 1932, seven burials have been found on a Texas plantation that was initially the location of a 17th-century Caddo Indian village. Of the seven excavated graves, one set of stays (an grownup male) was notably buried in a way inconsistent with conventional Caddoan burial practices and has lengthy been presupposed to be the stays of Sieur de Marle (a member of the French explorer La Salle’s final expedition). Diary accounts of La Salle’s expedition scribe report that Sieur de Marle died alongside a river close to an Indian village throughout a trek to Canada to search out assist for colonists left behind on the ill-fated Fort St. Louis. Moreover, two lead projectiles recovered from the grave have been ballistically analyzed and decided to be per ammunition utilized in 17th-century weaponry.

Within the 1980s, anthropologists requested entry to the stays for examine, however the cranium was lacking. Cranial measurements recorded in 1940 and 1962 (by two unbiased anthropologists) have been used to analyze the ancestry of this particular person; and the Giles-Elliot (G-E) discriminant perform was calculated to be 18.1, throughout the Anglo-European vary. Dietary isotope testing on non-cranial skeletal components decided that this unknown male’s weight-reduction plan was wealthy in animal/marine protein sources, which differs appreciably from Caddo Indian populations of that point interval. With a view to genetically assess this particular person’s biogeographic ancestry and to offer additional help that this particular person is of European descent, mitochondrial DNA (mtDNA) sequencing was carried out utilizing the Utilized Biosystems™ Precision ID mtDNA Entire Genome Panel. mtDNA sequencing of a number of sections from two totally different lengthy bones yielded compiled outcomes per both Haplogroup H or R, each predominantly European mtDNA haplogroups.

Additional anthropological calculations have been performed utilizing cranial measurements, FORDISC™ software program, and discriminant perform evaluation. Two-way, four-way, and multigroup discriminant perform analyses additional classify this set of unidentified stays as being White (European) in origin, with posterior chances of 0.999, 0.881 and 0.986, respectively. Mixed with historic data of Sieur de Marle’s loss of life, in addition to overlays of historic and up to date maps which exhibit that the plantation web site aligns with Joutel’s diary accounts of de Marle’s burial, these collective outcomes help that these stays are of a European male and will presumably belong to this distinguished member of La Salle’s expedition staff.

Design, Synthesis and Analysis of two,4,6-substituted Pyrimidine Derivatives as BACE-1 inhibitor: Believable lead for Alzheimer’s Illness

Alzheimer’s illness is likely one of the most typical neurodegenerative dysfunction afflicting a big mass of inhabitants. BACE-1 (β-secretase) is an aspartyl protease of the amyloidogenic pathway thought-about liable for Alzheimer’s illness (AD). Since, it catalyzes the speed limiting step of Aβ-42 manufacturing from amyloid precursor protein (APP),its inhibition is taken into account a viable therapeutic technique. We’ve reported the design of small molecular weight compounds speculated to be blood mind permeable as BACE-1 inhibitors. The clue for the design of this sequence is drawn from the beforehand designed sequence from our analysis group.Design and synthesis of two,4,6-substituted pyrimidine derivatives has been reported. In vitro FRET primarily based screening of synthesized derivatives was carried out to guage the BACE-1 inhibition profile.
Primarily based on the docking simulation research, a library of derivatives was designed, synthesized and evaluated for BACE-1 inhibition in-vitro. The docking research have been carried out on Glide (Schrodinger suite) and Molegro digital docker. Theoretical toxicity was predicted utilizing Osiris Property Explorer. The synthesized compounds have been examined for BACE-1 inhibition utilizing in vitro assay primarily based on Fluorescence Resonance Power Switch approach. The % inhibition was calculated as a measure of exercise.
The designed compounds revealed robust interactions with the specified amino acids of BACE-1 lively websites. The fragrant rings positioned at fourth and sixth place of pyrimidine ring occupied S1 and S3 substrate binding clefts whereas the amino group fashioned hydrogen bonding interactions with Asp32 and Asp228. In silico information ensured that the compounds have been orally bioavailable and mind permeable. The in vitro testing confirmed that the compounds inhibited BACE-1 at 10µM focus.
Compounds substituted with m-benzyloxy on one fragrant ring and o,p-di-chloro on one other fragrant ring displayed most BACE-1 inhibition. Compound 2.13A displayed excessive docking rating and was discovered to be most potent with IC50 of 6.92µM. The sequence displayed correlation between docking rating and BACE-1 inhibition profile.
Mitochondrial DNA analysis of the putative skeletal remains of Sieur de Marle: Genetic support for anthropological assessment of biogeographic ancestry

PAWER: protein array internet exploreR

Protein microarray is a well-established strategy for characterizing exercise ranges of 1000’s of proteins in a parallel method. Evaluation of protein microarray information is advanced and time-consuming, whereas present options are both outdated or difficult to make use of with out programming expertise. The standard information evaluation pipeline consists of a knowledge preprocessing step, adopted by differential expression evaluation, which is then put into context by way of purposeful enrichment. Usually, biologists would wish to assemble their very own workflow by combining a set of unrelated instruments to investigate experimental information. Supplied that the majority of those instruments are developed independently by varied bioinformatics teams, making them work collectively might be an actual problem.

ApoE4 protein
MBS539576-5x01mg 5x0.1mg
EUR 1155

ApoE4 protein
MBS537642-INQUIRE INQUIRE Ask for price

ApoE4 Recombinant Protein
40-138-01mg 0.1 mg
EUR 311.1
Description: ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Individuals heterozygous for the ApoE4 allele are at higher risk of late-onset Alzheimer’s disease. Recombinant human ApoE4 is a 34.4 kDa protein containing 300 amino acid residues.

ApoE4 Recombinant Protein
40-138-05mg 0.5 mg
EUR 437.1
Description: ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Individuals heterozygous for the ApoE4 allele are at higher risk of late-onset Alzheimer’s disease. Recombinant human ApoE4 is a 34.4 kDa protein containing 300 amino acid residues.

Recombinant Human ApoE4 Protein
PROTP02649-4 500ug
EUR 380.4
Description: ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Individuals heterozygous for the ApoE4 allele are at higher risk of late-onset Alzheimer’s disease. Recombinant human ApoE4 is a 34.4 kDa protein containing 300 amino acid residues.

Human ApoE4 Recombinant Protein
100-126 500 µg
EUR 196.35
Description: ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Individuals heterozygous for the ApoE4 allele are at higher risk of late-onset Alzheimer’s disease. Recombinant human ApoE4 is a 34.4 kDa protein containing 300 amino acid residues.

Human ApoE4 Recombinant Protein
100-126S 100 µg
EUR 92.4
Description: ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Individuals heterozygous for the ApoE4 allele are at higher risk of late-onset Alzheimer’s disease. Recombinant human ApoE4 is a 34.4 kDa protein containing 300 amino acid residues.

Human ApoE4 Recombinant Protein Lyophilized
IHUAPOE4RLY100UG each
EUR 341
Description: Human ApoE4 Recombinant Protein Lyophilized

Human ApoE4 Recombinant Protein Lyophilized
MBS8431232-INQUIRE INQUIRE Ask for price

Recombinant Human APOE4 Protein, His, E.coli-1mg
QP11051-1mg 1mg
EUR 458.4

Recombinant Human APOE4 Protein, His, E.coli-100ug
QP11051-100ug 100ug
EUR 186

Recombinant Human APOE4 Protein, His, E.coli-500ug
QP11051-500ug 500ug
EUR 284.4

APOE4 Apolipoprotein E4 Human Recombinant Protein
PROTP02649-1 Regular: 500ug
EUR 402
Description: Apolipoprotein E4 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing a total of 306 amino acids including a His Tag at N-terminus and having a molecular mass of 35.2kDa. The Accession # is P02649 VAR_000652.

Human ApoE4
MBS691668-01mg 0.1mg
EUR 300

Human ApoE4
MBS691668-05mg 0.5mg
EUR 450

Human ApoE4
MBS691668-5x05mg 5x0.5mg
EUR 1725

ApoE4 Antibody
5699-100 each
EUR 398.4

ApoE4 Antibody
5699-30T each
EUR 175.2

ApoE4 antibody
70R-12420 100 ug
EUR 385
Description: Rabbit polyclonal ApoE4 antibody

Human Apolipoprotein E / APOE4 Protein, His Tag (MALS verified)
APE-H52H9 100ug
EUR 2539.7
Description: Human APOE4, His Tag (APE-H52H9) is expressed from human 293 cells (HEK293). It contains AA Lys 19 - His 317 (Accession # P02649-1 (C130R)).

Human Apolipoprotein E / APOE4 Protein, Tag Free (MALS verified)
APE-H5215 100ug
EUR 2539.7
Description: Human APOE4 Protein, Tag Free (APE-H5215) is expressed from human 293 cells (HEK293). It contains AA Lys 19 - His 317 (Accession # P02649-1 (C130R)).

ApoE4, human recombinant
4699-100 each
EUR 170.4

ApoE4, human recombinant
4699-1000 each
EUR 548.4

ApoE4, human recombinant
4699-50 each
EUR 151.2

ApoE4, human recombinant
4699-500 each
EUR 339.6

ApoE4, human recombinant
4699-5000 each
EUR 1776

Biotinylated Human Apolipoprotein E / APOE4 Protein, His,Avitag™ (MALS verified)
APE-H52E7 25ug
EUR 1515.1
Description: Biotinylated Human APOE4 His,Avitag (APE-H52E7) is expressed from human 293 cells (HEK293). It contains AA Lys 19 - His 317 (Accession # P02649-1 (C130R)).

ApoE4 monoclonal antibody (4E4)
MBS566824-01mg 0.1mg
EUR 445

ApoE4 monoclonal antibody (4E4)
MBS566824-5x01mg 5x0.1mg
EUR 1955

Apolipoprotein E4 (APOE4) Antibody
abx342004-100g 100 µg Ask for price

Apolipoprotein E4 (APOE4) Antibody
abx342004-20g 20 µg
EUR 750

Apolipoprotein E4 (APOE4) Antibody
abx342004-50g 50 µg
EUR 2675

Mouse Monoclonal ApoE4 Antibody (4E4)
TA309573 100 µl Ask for price

Human Apoprotein E4 (APOE4) ELISA Kit
MBS3801700-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human Apoprotein E4 (APOE4) ELISA Kit
MBS3801700-48StripWells 48-Strip-Wells
EUR 550

Human Apoprotein E4 (APOE4) ELISA Kit
MBS3801700-5x96StripWells 5x96-Strip-Wells
EUR 3420

Human Apoprotein E4 (APOE4) ELISA Kit
MBS3801700-96StripWells 96-Strip-Wells
EUR 765

APOE4 (BSB-170), MMab, 0.1mL Concentrate
MBS373160-01mLConcentrate 0.1mL(Concentrate)
EUR 290

APOE4 (BSB-170), MMab, 0.1mL Concentrate
MBS373160-05mLConcentrate 0.5mL(Concentrate)
EUR 500

APOE4 (BSB-170), MMab, 0.1mL Concentrate
MBS373160-15mLRTU 15mL(RTU)
EUR 605

APOE4 (BSB-170), MMab, 0.1mL Concentrate
MBS373160-3mLRTU 3mL(RTU)
EUR 290

APOE4 (BSB-170), MMab, 0.1mL Concentrate
MBS373160-7mLRTU 7mL(RTU)
EUR 390

OKRC00173-96W - ApoE4 ELISA Kit (Human)
OKRC00173-96W 96Wells
EUR 725

Apolipoprotein E4, (ApoE4) (1mg) Human Recombinant
AE-102-10 1 mg
EUR 330

Human iPS Cell Line (Episomal, CD34+, ApoE4)
iPS16 1 Vial
EUR 1599.2

Apolipoprotein E4, (ApoE4) (1mg) 1-199 Human Recombinant
AE-103-10 1 mg
EUR 330

Apolipoprotein E4, (ApoE4) (1mg) 1-162 Human Recombinant
AE-104-10 1 mg
EUR 330

Apolipoprotein E4, (ApoE4) (1mg) 1-132 Human Recombinant
AE-105-10 1 mg
EUR 330

HighQC™ Human IPS Cell Line (Episomal, CD34+, ApoE4)
ABC-SC2105 1 vial Ask for price
Description: Footprint-free human iPS (induced pluripotent stem) cell line was derived from human bone marrow CD34+ mononuclear cells by ectopic expression of OCT4, SOX2, KLF4, c-MYC and Lin28 genes using episomal plasmids. The cells were derived using morphological selection criteria and without the use of fluorescent marker or drug selection. When cultured under standard human ES cell culture conditions, the morphology of human iPS cells are identical to that of human ES cells. The cells also express the pluripotency markers TRA-1-60, SSEA-3 and Oct4, and demonstrate strong endogenous alkaline phosphatase activity.

HighQC™ Human IPSC-Derived Neural Stem Cell-Alzheimer's Disease Patient (APOE4 HOM)
ABC-SC0059T 1 vial Ask for price
Description: Gentaur Human iPSC-Derived Neural Stem Cells (NSCs) are derived from integration-free, induced pluripotent stem cells (iPSCs) under fully defined neural induction conditions. The NSCs express typical markers of cerebral cortical neural stem and progenitor cells such as PAX6, FOXG1 and nestin, and spontaneously form polarized neural tube-like rosette structures when plated as a monolayer in culture (see below). Additionally, Gentaur NSCs are capable of generating a spectrum of cerebral cortical excitatory and inhibitory neurons that are electrically active and have the ability to form functional synapses and circuits in vitro. After thawing and plating, the neural stem cells terminally differentiate to acquire mature electrophysiological properties, and form functional synaptic networks over a period of 40 ~ 50 days.Gentaur NSCs are easy to differentiate to neurons or mixed neural cell types, following our protocols and using our tailored media and reagent bundles. A highly pure population of neurons can be generated from Gentaur NSCs following the synchronous differentiation protocol. Using our specialized coating reagents, neurons derived from Gentaur NSCs can be maintained in culture long-term (andgt;1 year). NSCs are available from multiple donors to suit your research needs and have been characterized extensively.

ApoE3 protein
30R-2381 1 mg
EUR 126
Description: Purified recombinant Human ApoE3 protein

ApoE2 protein
30R-2387 1 mg
EUR 150
Description: Purified recombinant Human ApoE2 protein

ApoE3 protein
30R-AA016 500 ug
EUR 312
Description: Purified recombinant Human ApoE3 protein

ApoE2 protein
30R-AA019 500 ug
EUR 312
Description: Purified recombinant Human ApoE2 protein

ApoE3 protein
MBS538089-05mg 0.5mg
EUR 465

ApoE3 protein
MBS538089-5x05mg 5x0.5mg
EUR 1945

ApoE2 protein
MBS538318-05mg 0.5mg
EUR 465

ApoE2 protein
MBS538318-5x05mg 5x0.5mg
EUR 1945

Recombinant Human ApoE2 Protein
PROTP02649-2 500ug
EUR 380.4
Description: ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. It’s interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Compared with E3 and E4, E2 exhibits the lowest receptor binding affinity. E2 allele carriers had significantly lower levels of total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol, as well as increased ApoE levels. Recombinant human ApoE2 is a 34.3 kDa protein containing 300 amino acid residues.

Recombinant Human ApoE3 Protein
PROTP02649-3 500ug
EUR 380.4
Description: ApoE3 belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. E3 is the most common isoform and is present in 40-90% of the population. Recombinant human ApoE3 is a 34.0 kDa protein containing 299 amino acid residues.

Human ApoE3 protein W. Blot +ve control
APOE31-C 100 ul
EUR 343.2

ApoE3 Recombinant Protein
40-136-01mg 0.1 mg
EUR 311.1
Description: ApoE3 belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. E3 is the most common isoform and is present in 40-90% of the population. Recombinant human ApoE3 is a 34.4 kDa protein containing 300 amino acid residues.

ApoE3 Recombinant Protein
40-136-05mg 0.5 mg
EUR 437.1
Description: ApoE3 belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. E3 is the most common isoform and is present in 40-90% of the population. Recombinant human ApoE3 is a 34.4 kDa protein containing 300 amino acid residues.

ApoE2 Recombinant Protein
40-140-01mg 0.1 mg
EUR 311.1
Description: ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. It’s interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Compared with E3 and E4, E2 exhibits the lowest receptor binding affinity. E2 allele carriers had significantly lower levels of total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol, as well as increased ApoE levels. Recombinant human ApoE2 is a 34.3 kDa protein containing 300 amino acid residues.

ApoE2 Recombinant Protein
40-140-05mg 0.5 mg
EUR 437.1
Description: ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. It’s interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Compared with E3 and E4, E2 exhibits the lowest receptor binding affinity. E2 allele carriers had significantly lower levels of total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol, as well as increased ApoE levels. Recombinant human ApoE2 is a 34.3 kDa protein containing 300 amino acid residues.

Purified recombinant Human ApoE2 protein
MBS5308520-05mg 0.5mg
EUR 480

Purified recombinant Human ApoE2 protein
MBS5308520-5x05mg 5x0.5mg
EUR 2010

Purified recombinant Human ApoE3 protein
MBS5308521-01mg 0.1mg
EUR 255

Purified recombinant Human ApoE3 protein
MBS5308521-5x01mg 5x0.1mg
EUR 990

Human Apolipoprotein E / APOE3 Protein, His Tag
APE-H5246 100ug
EUR 2517.9
Description: Human APOE3, His Tag (APE-H5246) is expressed from human 293 cells (HEK293). It contains AA Lys 19 - His 317 (Accession # P02649-1).

Apoe (NM_009696) Mouse Recombinant Protein
E45M42377M5 20 ug
EUR 1924.54

ApoE protein
30-1053 50 ug
EUR 1162
Description: Purified native Human ApoE protein

ApoE protein
30-AA30 100 ug
EUR 445
Description: Purified native Human ApoE protein

ApoE protein
MBS537055-INQUIRE INQUIRE Ask for price

ApoE protein
MBS5303616-005mg 0.05mg
EUR 1960

ApoE protein
MBS5303616-5x005mg 5x0.05mg
EUR 8600

Rabbit Anti-Human ApoE3 protein antiserum #1
APOE31-S 100 ul
EUR 548.4

Recombinant Human APOE3 Protein, His, E.coli-1mg
QP10522-1mg 1mg
EUR 381.6

Recombinant Human APOE3 Protein, His, E.coli-100ug
QP10522-100ug 100ug
EUR 186

Recombinant Human APOE3 Protein, His, E.coli-500ug
QP10522-500ug 500ug
EUR 241.2

Human ApoE2 Recombinant Protein
100-124 500 µg
EUR 196.35
Description: ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. Its interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Compared with E3 and E4, E2 exhibits the lowest receptor binding affinity. E2 allele carriers had significantly lower levels of total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol, as well as increased ApoE levels. Recombinant human ApoE2 is a 34.3 kDa protein containing 300 amino acid residues.

Human ApoE2 Recombinant Protein
100-124S 100 µg
EUR 92.4
Description: ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. Its interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Compared with E3 and E4, E2 exhibits the lowest receptor binding affinity. E2 allele carriers had significantly lower levels of total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol, as well as increased ApoE levels. Recombinant human ApoE2 is a 34.3 kDa protein containing 300 amino acid residues.

Human ApoE3 Recombinant Protein
100-125 500 µg
EUR 196.35
Description: ApoE3 belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solubilization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. E3 is the most common isoform and is present in 40-90% of the population. Recombinant human ApoE3 is a 34.0 kDa protein containing 300 amino acid residues.

Human ApoE3 Recombinant Protein
100-125S 100 µg
EUR 92.4
Description: ApoE3 belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solubilization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. E3 is the most common isoform and is present in 40-90% of the population. Recombinant human ApoE3 is a 34.0 kDa protein containing 300 amino acid residues.

Human Apolipoprotein E / APOE2 Protein, His Tag (SPR verified)
APE-H52H6 100ug
EUR 2180
Description: Human APOE2, His Tag (APE-H52H6) is expressed from human 293 cells (HEK293). It contains AA Lys 19 - His 317 (Accession # P02649-1 (R176C)).

Human Apolipoprotein E / APOE3 Protein, Tag Free (MALS verified)
APE-H5213 1mg
EUR 2471.7
Description: Human APOE3 Protein, Tag Free (APE-H5213) is expressed from human 293 cells (HEK293). It contains AA Lys 19 - His 317 (Accession # P02649-1).

Human Apolipoprotein E / APOE3 Protein, Tag Free (MALS verified)
APE-H5216 100ug
EUR 2517.9
Description: Human APOE3 Protein, Tag Free (APE-H5216) is expressed from human 293 cells (HEK293). It contains AA Lys 19 - His 317 (Accession # P02649-1 ).

Apolipoprotein E (APOE) (NM_000041) Human Recombinant Protein
E45H42059M5 20 ug
EUR 785.42

Human APOE Protein Lysate
MBS137389-002mg 0.02mg
EUR 365

Human APOE Protein Lysate
MBS137389-5x002mg 5x0.02mg
EUR 1410

Human ApoE2 Recombinant Protein Lyophilized
IHUAPOE2RLY100UG each
EUR 341
Description: Human ApoE2 Recombinant Protein Lyophilized

Human ApoE3 Recombinant Protein Lyophilized
IHUAPOE3RLY100UG each
EUR 341
Description: Human ApoE3 Recombinant Protein Lyophilized

Human ApoE2 Recombinant Protein Lyophilized
MBS8431230-INQUIRE INQUIRE Ask for price

Human ApoE3 Recombinant Protein Lyophilized
MBS8431231-INQUIRE INQUIRE Ask for price

Human Apolipoprotein E / APOE2 (R154S) Protein, His Tag
APE-H5256 100ug
EUR 2801.3
Description: Human APOE2 (R154S), His Tag (APE-H5256) is expressed from human 293 cells (HEK293). It contains AA Lys 19 - His 317 (Accession # P02649-1 (R154S)).

APOE3 Apolipoprotein E3 Human Recombinant Protein
PROTP02649 Regular: 500ug
EUR 250
Description: APOE3 Human Recombinant (19-317) produced in E. coli is a single, non-glycosylated, polypeptide chain containing 306 amino acids and having a molecular mass of 35.2kDa.The APOE is fused to a Met and a 6 amino acid His tag [M-HHHHHH] at N-terminus and purified by proprietary chromatographic techniques.

Human APOE Protein Lysate 20ug
IHUAPOEPLLY20UG each
EUR 213
Description: Human APOE Protein Lysate 20ug

Biotinylated Human Apolipoprotein E / APOE3 Protein, His,Avitag™ (MALS verified)
APE-H52E3 25ug
EUR 1515.1
Description: Biotinylated Human APOE3, His,Avitag (APE-H52E3) is expressed from human 293 cells (HEK293). It contains AA Lys 19 - His 317 (Accession # P02649-1).

Biotinylated Human Apolipoprotein E / APOE2 Protein, His,Avitag™ (MALS verified)
APE-H52E5 25ug
EUR 1515.1
Description: Biotinylated Human APOE2, His,Avitag (APE-H52E5) is expressed from human 293 cells (HEK293). It contains AA Lys 19 - His 317 (Accession # P02649-1 (R176C)).

Rat Apolipoprotein E (APOE) Protein
abx065427-100g 100 µg
EUR 612.5

Rat Apolipoprotein E (APOE) Protein
20-abx065427
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  • 10 ug
  • 50 ug
  • 100 ug
  • 200 ug
  • 1 mg

Rat Apolipoprotein E (APOE) Protein
abx065427-10g 10 µg
EUR 237.5

Rat Apolipoprotein E (APOE) Protein
abx065427-50g 50 µg
EUR 425

Pig Apolipoprotein E (APOE) Protein
20-abx652555
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  • 10 ug
  • 50 ug
  • 100 ug
  • 200 ug
  • 1 mg

Pig Apolipoprotein E (APOE) Protein
abx652555-5mg 5 mg
EUR 5300

Dog Apolipoprotein E (APOE) Protein
20-abx168028
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  • 10 ug
  • 50 ug
  • 100 ug
  • 200 ug
  • 1 mg

Dog Apolipoprotein E (APOE) Protein
abx168028-1ml 1 ml
EUR 450

Recombinant Human APOE Protein
E30P00944A 50 ug
EUR 295

Recombinant Human APOE protein
MBS1561213-005mg 0.05mg
EUR 320

Recombinant Human APOE protein
MBS1561213-01mg 0.1mg
EUR 410

Recombinant Human APOE protein
MBS1561213-5x01mg 5x0.1mg
EUR 1520

Recombinant Human APOE Protein
MBS8248560-001mg 0.01mg
EUR 170

Recombinant Human APOE Protein
MBS8248560-005mg 0.05mg
EUR 270

Recombinant Human APOE Protein
MBS8248560-05mg 0.5mg
EUR 995

Recombinant Human APOE Protein
MBS8248560-5x05mg 5x0.5mg
EUR 4405

Recombinant Mouse APOE Protein
MBS8248561-001mg 0.01mg
EUR 250

Recombinant Mouse APOE Protein
MBS8248561-005mg 0.05mg
EUR 545

Recombinant Mouse APOE Protein
MBS8248561-05mg 0.5mg
EUR 1905

Recombinant Mouse APOE Protein
MBS8248561-5x05mg 5x0.5mg
EUR 8485

Recombinant Mouse Apolipo Protein E/ApoE Protein (C-6His)
MBS2553444-001mg 0.01mg
EUR 175

Recombinant Mouse Apolipo Protein E/ApoE Protein (C-6His)
MBS2553444-005mg 0.05mg
EUR 485

Recombinant Mouse Apolipo Protein E/ApoE Protein (C-6His)
MBS2553444-5x005mg 5x0.05mg
EUR 2165

Recombinant Human Apolipo Protein E/ApoE Protein (C-6His)
MBS2552366-001mg 0.01mg
EUR 85

Recombinant Human Apolipo Protein E/ApoE Protein (C-6His)
MBS2552366-005mg 0.05mg
EUR 115

Recombinant Human Apolipo Protein E/ApoE Protein (C-6His)
MBS2552366-5x005mg 5x0.05mg
EUR 520

APOE Protein Vector (Rat) (pPM-C-HA)
PV254108 500 ng
EUR 723.6

Mouse Apolipoprotein E (APOE) Protein
abx065426-100g 100 µg
EUR 587.5

Mouse Apolipoprotein E (APOE) Protein
20-abx065426
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  • 10 ug
  • 50 ug
  • 100 ug
  • 200 ug
  • 1 mg

Mouse Apolipoprotein E (APOE) Protein
abx065426-10g 10 µg
EUR 225

Mouse Apolipoprotein E (APOE) Protein
abx065426-50g 50 µg
EUR 400

Human Apolipoprotein E (APOE) Protein
abx065429-100g 100 µg
EUR 425

Human Apolipoprotein E (APOE) Protein
20-abx065429
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  • 10 ug
  • 50 ug
  • 100 ug
  • 200 ug
  • 1 mg

Human Apolipoprotein E (APOE) Protein
abx065429-10g 10 µg
EUR 187.5

Human Apolipoprotein E (APOE) Protein
abx065429-50g 50 µg
EUR 300

Human Apolipoprotein E (APOE) Protein
abx694213-10nmol 10 nmol
EUR 600

Human Apolipoprotein E (APOE) Protein
abx694213-5nmol 5 nmol
EUR 400

APOE Protein Vector (Rat) (pPB-C-His)
PV254106 500 ng
EUR 723.6

APOE Protein Vector (Rat) (pPB-N-His)
PV254107 500 ng
EUR 723.6

APOE Protein Vector (Rat) (pPM-C-His)
PV254109 500 ng
EUR 723.6

Rabbit Apolipoprotein E (APOE) Protein
20-abx652556
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  • 10 ug
  • 50 ug
  • 100 ug
  • 200 ug
  • 1 mg

Rabbit Apolipoprotein E (APOE) Protein
abx652556-5mg 5 mg
EUR 5300

APOE Protein Vector (Mouse) (pPM-C-HA)
PV155300 500 ng
EUR 723.6

APOE Protein Vector (Human) (pPM-C-HA)
PV002127 500 ng
EUR 394.8

APOE Protein Vector (Mouse) (pPB-C-His)
PV155298 500 ng
EUR 723.6

APOE Protein Vector (Mouse) (pPB-N-His)
PV155299 500 ng
EUR 723.6

APOE Protein Vector (Mouse) (pPM-C-His)
PV155301 500 ng
EUR 723.6

APOE Protein Vector (Human) (pPB-C-His)
PV002125 500 ng
EUR 394.8

APOE Protein Vector (Human) (pPB-N-His)
PV002126 500 ng
EUR 394.8

APOE Protein Vector (Human) (pPM-C-His)
PV002128 500 ng
EUR 394.8

OCOA17576-20UG - APOE Protein Lysate
OCOA17576-20UG 20ug
EUR 169

Recombinant Pig APOE protein, N-His Tag
IMP-3575 10µg
EUR 432
Description: Recombinant Proteins

Recombinant Dog APOE protein, N-His Tag
IMP-3578 10µg
EUR 432
Description: Recombinant Proteins

Recombinant Rat APOE protein, N-His Tag
IMP-3581 10µg
EUR 432
Description: Recombinant Proteins

Recombinant Human ApoE protein (C-6His)
CD02311-10ug 10ug
EUR 24
Description: Recombinant Human Apolipoprotein E is produced by our Mammalian expression system and the target gene encoding Lys19-His317 is expressed with a 6His tag at the C-terminus.

Recombinant Human ApoE protein (C-6His)
CD02311-50ug 50ug
EUR 94
Description: Recombinant Human Apolipoprotein E is produced by our Mammalian expression system and the target gene encoding Lys19-His317 is expressed with a 6His tag at the C-terminus.

Recombinant Mouse APOE protein (C-6His)
CD00621-10ug 10ug
EUR 247
Description: Recombinant Mouse Apolipoprotein E is produced by our Mammalian expression system and the target gene encoding Glu19-Gln311 is expressed with a 6His tag at the C-terminus.

Recombinant Mouse APOE protein (C-6His)
CD00621-50ug 50ug
EUR 976
Description: Recombinant Mouse Apolipoprotein E is produced by our Mammalian expression system and the target gene encoding Glu19-Gln311 is expressed with a 6His tag at the C-terminus.

APOE Protein Vector (Human) (pPB-His-MBP)
PV322902 500 ng
EUR 394.8

APOE Protein Vector (Human) (pPB-His-GST)
PV322903 500 ng
EUR 394.8

Recombinant Mouse Apoe protein, N-His Tag
IMP-1451 20µg
EUR 720
Description: Recombinant Proteins

Recombinant Mouse Apoe protein, N-His Tag
IMP-1452 20µg
EUR 720
Description: Recombinant Proteins

Recombinant Mouse Apoe protein, C-His Tag
IMP-1455 20µg
EUR 720
Description: Recombinant Proteins

Recombinant Human APOE protein, N-His Tag
IMP-1727 100µg
EUR 2400
Description: Recombinant Proteins

Recombinant Human APOE protein, N-His Tag
IMP-3573 10µg
EUR 432
Description: Recombinant Proteins

APOE Protein Vector (Human) (pPM-N-D-C-HA)
PV322904 500 ng
EUR 662.4

Goat Anti-Human ApoE protein antiserum #1
APOE11-S 100 ul
EUR 548.4

Recombinant Cattle APOE protein, N-His Tag
IMP-3580 10µg
EUR 432
Description: Recombinant Proteins

APOE Protein Vector (Human) (pPM-N-D-C-His)
PV322905 500 ng
EUR 662.4

Recombinant Rat APOE protein, N-His-GST Tag
IMP-3576 10µg
EUR 432
Description: Recombinant Proteins

Recombinant Human APOE Protein, His-tagged
APOE-17H 50ug
EUR 398.4
Description: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Recombinant Mouse Apoe protein, His-tagged
Apoe-25M 20ug 1mg/ml
EUR 558.4
Description: Store at -lt- -20 centigrade, stable for 6 months after receipt.Please minimize freeze-thaw cycles.

Recombinant Human Apolipoprotein E (ApoE) Protein
MBS286103-01mg 0.1mg
EUR 440

Recombinant Human Apolipoprotein E (ApoE) Protein
MBS286103-05mg 0.5mg
EUR 1200

Recombinant Human Apolipoprotein E (ApoE) Protein
MBS286103-1mg 1mg
EUR 1665

Recombinant Human Apolipoprotein E (ApoE) Protein
MBS286103-5x1mg 5x1mg
EUR 7480

Recombinant Human Apolipoprotein E/ApoE Protein
MBS9144256-002mg 0.02mg
EUR 165

Recombinant Human Apolipoprotein E/ApoE Protein
MBS9144256-005mg 0.05mg
EUR 195

Recombinant Human Apolipoprotein E/ApoE Protein
MBS9144256-01mg 0.1mg
EUR 250

Recombinant Human Apolipoprotein E/ApoE Protein
MBS9144256-5x01mg 5x0.1mg
EUR 945

Recombinant Human Apolipoprotein E/ApoE Protein
RP00306 10 μg
EUR 7.09

Recombinant Mouse Apolipoprotein E/APOE Protein
RP00640 10μg
EUR 162.96

Recombinant Human Apolipoprotein E/ApoE Protein
RP01443 50μg
EUR 26.21

Recombinant Rat APOE Protein, His (Fc)-Avi-tagged
APOE-382R 50ug
EUR 2398.4
Description: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.

Recombinant Mouse APOE protein, N-His-GST Tag
IMP-3574 10µg
EUR 432
Description: Recombinant Proteins

Recombinant Mouse Apoe protein, N-His & C-Myc Tag
IMP-1453 20µg
EUR 720
Description: Recombinant Proteins

Recombinant Mouse Apoe protein, N-His & C-Myc Tag
IMP-1454 20µg
EUR 720
Description: Recombinant Proteins

Recombinant Human ApoE protein W. Blot +ve control
APOE11-C 100 ul
EUR 343.2

Recombinant Human ApoE protein W. Blot +ve control
APOE12-C 100 ul
EUR 343.2

Recombinant Rabbit APOE protein, N-His & C-Myc Tag
IMP-1448 20µg
EUR 720
Description: Recombinant Proteins

Recombinant Human APOE Protein, His (Fc)-Avi-tagged
APOE-364H 50ug
EUR 2398.4
Description: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
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