Mitochondrial DNA analysis of the putative skeletal remains of Sieur de Marle: Genetic support for anthropological assessment of biogeographic ancestry

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Mitochondrial DNA analysis of the putative skeletal remains of Sieur de Marle: Genetic support for anthropological assessment of biogeographic ancestry

In 1932, seven burials have been found on a Texas plantation that was initially the location of a 17th-century Caddo Indian village. Of the seven excavated graves, one set of stays (an grownup male) was notably buried in a way inconsistent with conventional Caddoan burial practices and has lengthy been presupposed to be the stays of Sieur de Marle (a member of the French explorer La Salle’s final expedition). Diary accounts of La Salle’s expedition scribe report that Sieur de Marle died alongside a river close to an Indian village throughout a trek to Canada to search out assist for colonists left behind on the ill-fated Fort St. Louis. Moreover, two lead projectiles recovered from the grave have been ballistically analyzed and decided to be per ammunition utilized in 17th-century weaponry.

Within the 1980s, anthropologists requested entry to the stays for examine, however the cranium was lacking. Cranial measurements recorded in 1940 and 1962 (by two unbiased anthropologists) have been used to analyze the ancestry of this particular person; and the Giles-Elliot (G-E) discriminant perform was calculated to be 18.1, throughout the Anglo-European vary. Dietary isotope testing on non-cranial skeletal components decided that this unknown male’s weight-reduction plan was wealthy in animal/marine protein sources, which differs appreciably from Caddo Indian populations of that point interval. With a view to genetically assess this particular person’s biogeographic ancestry and to offer additional help that this particular person is of European descent, mitochondrial DNA (mtDNA) sequencing was carried out utilizing the Utilized Biosystems™ Precision ID mtDNA Entire Genome Panel. mtDNA sequencing of a number of sections from two totally different lengthy bones yielded compiled outcomes per both Haplogroup H or R, each predominantly European mtDNA haplogroups.

Additional anthropological calculations have been performed utilizing cranial measurements, FORDISC™ software program, and discriminant perform evaluation. Two-way, four-way, and multigroup discriminant perform analyses additional classify this set of unidentified stays as being White (European) in origin, with posterior chances of 0.999, 0.881 and 0.986, respectively. Mixed with historic data of Sieur de Marle’s loss of life, in addition to overlays of historic and up to date maps which exhibit that the plantation web site aligns with Joutel’s diary accounts of de Marle’s burial, these collective outcomes help that these stays are of a European male and will presumably belong to this distinguished member of La Salle’s expedition staff.

Design, Synthesis and Analysis of two,4,6-substituted Pyrimidine Derivatives as BACE-1 inhibitor: Believable lead for Alzheimer’s Illness

Alzheimer’s illness is likely one of the most typical neurodegenerative dysfunction afflicting a big mass of inhabitants. BACE-1 (β-secretase) is an aspartyl protease of the amyloidogenic pathway thought-about liable for Alzheimer’s illness (AD). Since, it catalyzes the speed limiting step of Aβ-42 manufacturing from amyloid precursor protein (APP),its inhibition is taken into account a viable therapeutic technique. We’ve reported the design of small molecular weight compounds speculated to be blood mind permeable as BACE-1 inhibitors. The clue for the design of this sequence is drawn from the beforehand designed sequence from our analysis group.Design and synthesis of two,4,6-substituted pyrimidine derivatives has been reported. In vitro FRET primarily based screening of synthesized derivatives was carried out to guage the BACE-1 inhibition profile.
Primarily based on the docking simulation research, a library of derivatives was designed, synthesized and evaluated for BACE-1 inhibition in-vitro. The docking research have been carried out on Glide (Schrodinger suite) and Molegro digital docker. Theoretical toxicity was predicted utilizing Osiris Property Explorer. The synthesized compounds have been examined for BACE-1 inhibition utilizing in vitro assay primarily based on Fluorescence Resonance Power Switch approach. The % inhibition was calculated as a measure of exercise.
The designed compounds revealed robust interactions with the specified amino acids of BACE-1 lively websites. The fragrant rings positioned at fourth and sixth place of pyrimidine ring occupied S1 and S3 substrate binding clefts whereas the amino group fashioned hydrogen bonding interactions with Asp32 and Asp228. In silico information ensured that the compounds have been orally bioavailable and mind permeable. The in vitro testing confirmed that the compounds inhibited BACE-1 at 10µM focus.
Compounds substituted with m-benzyloxy on one fragrant ring and o,p-di-chloro on one other fragrant ring displayed most BACE-1 inhibition. Compound 2.13A displayed excessive docking rating and was discovered to be most potent with IC50 of 6.92µM. The sequence displayed correlation between docking rating and BACE-1 inhibition profile.
Mitochondrial DNA analysis of the putative skeletal remains of Sieur de Marle: Genetic support for anthropological assessment of biogeographic ancestry

PAWER: protein array internet exploreR

Protein microarray is a well-established strategy for characterizing exercise ranges of 1000’s of proteins in a parallel method. Evaluation of protein microarray information is advanced and time-consuming, whereas present options are both outdated or difficult to make use of with out programming expertise. The standard information evaluation pipeline consists of a knowledge preprocessing step, adopted by differential expression evaluation, which is then put into context by way of purposeful enrichment. Usually, biologists would wish to assemble their very own workflow by combining a set of unrelated instruments to investigate experimental information. Supplied that the majority of those instruments are developed independently by varied bioinformatics teams, making them work collectively might be an actual problem.

Recombinant Human ApoE4 Protein
PROTP02649-4 500ug
EUR 380.4
Description: ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Individuals heterozygous for the ApoE4 allele are at higher risk of late-onset Alzheimer’s disease. Recombinant human ApoE4 is a 34.4 kDa protein containing 300 amino acid residues.

ApoE4, human recombinant
4699-100
EUR 170.4

ApoE4, human recombinant
4699-1000
EUR 548.4

ApoE4, human recombinant
4699-50
EUR 151.2

ApoE4, human recombinant
4699-500
EUR 339.6

ApoE4, human recombinant
4699-5000
EUR 1776

APOE4 Apolipoprotein E4 Human Recombinant Protein
PROTP02649-1 Regular: 500ug
EUR 402
Description: Apolipoprotein E4 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing a total of 306 amino acids including a His Tag at N-terminus and having a molecular mass of 35.2kDa. The Accession # is P02649 VAR_000652.

Recombinant Human APOE4 Protein, His, E.coli-100ug
QP11051-100ug 100ug
EUR 186

Recombinant Human APOE4 Protein, His, E.coli-1mg
QP11051-1mg 1mg
EUR 458.4

Recombinant Human APOE4 Protein, His, E.coli-500ug
QP11051-500ug 500ug
EUR 284.4

Protein A protein
30R-1304 100 ug
EUR 333.6
Description: Purified recombinant S.aureus Protein A protein

pLDH Protein Protein
abx061407-1mg 1 mg
EUR 3166.8

pLDH Protein Protein
abx061408-1mg 1 mg
EUR 3166.8

Protein A Protein
abx061461-10mg 10 mg
EUR 526.8

Protein A Protein
abx069907-100mg 100 mg
EUR 560.4

Protein G Protein
20-abx260044
  • EUR 2364.00
  • EUR 560.40
  • EUR 276.00
  • 100 mg
  • 10 mg
  • 1 mg

Protein G Protein
20-abx262181
  • EUR 927.60
  • EUR 393.60
  • EUR 276.00
  • 100 mg
  • 10 mg
  • 1 mg

Protein L Protein
20-abx262993
  • EUR 1062.00
  • EUR 393.60
  • EUR 276.00
  • 100 mg
  • 10 mg
  • 1 mg

Protein L Protein
20-abx262994
  • EUR 1062.00
  • EUR 393.60
  • EUR 276.00
  • 100 mg
  • 10 mg
  • 1 mg

Protein-Export Protein SecB (SecB) Protein
20-abx261442
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 25 ug
  • 5 ug

Protein Export Protein SecB Recombinant Protein
PROTP0AG86 Regular: 25ug
EUR 380.4
Description: Recombinant E.Coli SecB produced in E.Coli is a single, non-glycosylated polypeptide chain containing 155 amino acids and having a molecular mass of 17.2 kDa. SecB was over-expressed in E. coli and purified by conventional chromatography.

Polyadenylate-Binding Protein-Interacting Protein 2 Protein
20-abx260556
  • EUR 3433.20
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 25 ug
  • 5 ug

Heat Shock Protein-Binding Protein 1 Protein
20-abx262435
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Protein-A Staphylococcal Protein A Recombinant Protein
PROTP38507 Regular: 100mg
EUR 628.8
Description: Recombinant Staphylococcal Protein A produced in E.Coli is a non-glycosylated, Polypeptide chain having a molecular mass of 45 kDa.;Recombinant Staphylococcal Protein A is purified by proprietary chromatographic techniques.

Protein CutA Recombinant Protein
91-235 0.05 mg
EUR 821.4
Description: Protein CutA (CUTA) posseses a signal peptide and is widely expressed in brain. CUTA mayforms part of a complex of membrane proteins attached to acetylcholinesterase (AChE). CUTA takes part in cellular tolerance to a broad range of divalent cations other than copper. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found.

Protein FAM3C Recombinant Protein
91-317 0.05 mg
EUR 651.3
Description: FAM3C, also called interleukin-like EMT inducer, usually exist in most secretory epithelia. It belongs to the FAM3 family according to their sequence similarities. The up-regulation and/or mislocalization in breast cancer and liver carcinoma cells of FAM3C is strongly correlated with metastasis formation and survival. FAM3C can be involved in retinal laminar formation and promote epithelial to mesenchymal transition.

Protein FAM3D Recombinant Protein
91-318 0.05 mg
EUR 651.3
Description: Protein FAM3D is a novel cytokine-like protein that belongs to the FAM3 family. Human FAM3D is synthesized as a 224 amino acid precursor that contains a 25 amino acid signal sequence and a 199 amino acid mature chain. FAM3D is identified based on structural, but not sequence, homology to short chain cytokines including IL-2, IL-4 and GM-CSF. FAM3 proteins are four helix bundle cytokines with four conserved cysteines in all members (FAM3A-D). FAM3B is highly expressed in alpha and beta cells of the pancreas and is being investigated as a potential contributor to beta cell death and development of Type I Diabetes.

Protein Amnionless (AMN) Protein
20-abx263207
  • EUR 276.00
  • EUR 1779.60
  • EUR 393.60
  • 1 µg
  • 50 ug
  • 5 ug

Ribosomal Protein S14 Protein
20-abx263299
  • EUR 276.00
  • EUR 1930.80
  • EUR 393.60
  • 1 µg
  • 50 ug
  • 5 ug

Protein BEX1 (BEX1) Protein
20-abx263364
  • EUR 1930.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 10 ug
  • 2 µg

Ribosomal Protein S19 Protein
20-abx263367
  • EUR 1930.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 10 ug
  • 2 µg

Ribosomal Protein S24 Protein
20-abx263370
  • EUR 1930.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 10 ug
  • 2 µg

Ribosomal Protein L30 Protein
20-abx263376
  • EUR 1930.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 10 ug
  • 2 µg

Ribosomal Protein L31 Protein
20-abx263395
  • EUR 1930.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 10 ug
  • 2 µg

Cys-Protein G Protein
20-abx260045
  • EUR 2364.00
  • EUR 560.40
  • EUR 276.00
  • 100 mg
  • 10 mg
  • 1 mg

Protein GLC8 (GLC8) Protein
20-abx260445
  • EUR 276.00
  • EUR 2798.40
  • EUR 393.60
  • 10 ug
  • 1 mg
  • 50 ug

Protein Max (MAX) Protein
20-abx260587
  • EUR 3433.20
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 25 ug
  • 5 ug

Protein CutA (CUTA) Protein
20-abx260588
  • EUR 3433.20
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 25 ug
  • 5 ug

Ribosomal Protein S3A Protein
20-abx260901
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Ribosomal Protein S10 Protein
20-abx261043
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Ribosomal Protein S12 Protein
20-abx261079
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Ribosomal Protein L26 Protein
20-abx261104
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Protein SET (SET) Protein
20-abx261106
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Ribosomal Protein L11 Protein
20-abx261115
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Centromere Protein-M Protein
20-abx261135
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Ribosomal Protein L35A Protein
20-abx261171
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Ribosomal Protein L34 Protein
20-abx261172
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Centromere Protein-P Protein
20-abx261213
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Ribosomal Protein 4X Protein
20-abx261221
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Centromere Protein-Q Protein
20-abx261234
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Centromere Protein-U Protein
20-abx261241
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Protein LZIC (LZIC) Protein
20-abx261245
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Protein BRICK1 (BRK1) Protein
20-abx261249
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Protein-c Receptor Protein
20-abx261298
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Surfactant Protein D Protein
20-abx261338
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Centromere Protein-H Protein
20-abx261515
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Ribosomal Protein S13 Protein
20-abx261933
  • EUR 5388.00
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Protein KIBRA (WWC1) Protein
20-abx261958
  • EUR 5388.00
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Ribosomal Protein L18A Protein
20-abx261962
  • EUR 5388.00
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Ribosomal Protein S18 Protein
20-abx262032
  • EUR 5388.00
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Centromere Protein-A Protein
20-abx262074
  • EUR 5805.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Centromere Protein-B Protein
20-abx262075
  • EUR 5805.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Protein AMBP (AMBP) Protein
20-abx262116
  • EUR 393.60
  • EUR 844.80
  • EUR 276.00
  • 100 ug
  • 1 mg
  • 20 ug

Protein A / G Protein
20-abx262179
  • EUR 927.60
  • EUR 393.60
  • EUR 276.00
  • 100 mg
  • 10 mg
  • 1 mg

Protein A / G Protein
20-abx262182
  • EUR 927.60
  • EUR 393.60
  • EUR 276.00
  • 100 mg
  • 10 mg
  • 1 mg

Ribosomal Protein L23A Protein
20-abx262616
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Ribosomal Protein L22 Protein
20-abx262641
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Ribosomal Protein S16 Protein
20-abx262643
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Ribosomal Protein S20 Protein
20-abx262728
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Protein JTB (JTB) Protein
20-abx262811
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Protein AMBP (AMBP) Protein
20-abx262923
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Protein L-Cys Protein
20-abx263053
  • EUR 1128.00
  • EUR 393.60
  • EUR 276.00
  • 100 mg
  • 10 mg
  • 1 mg

Protein L Cys Protein
20-abx263054
  • EUR 1128.00
  • EUR 393.60
  • EUR 276.00
  • 100 mg
  • 10 mg
  • 1 mg

Cys-Protein-L Protein
20-abx263055
  • EUR 1128.00
  • EUR 393.60
  • EUR 276.00
  • 100 mg
  • 10 mg
  • 1 mg

Protein G Recombinant Protein
96-655 2 mg
EUR 374.1
Description: Protein G is an immunoglobulin-binding protein expressed in group C and G Streptococcal bacteria much like Protein A but with differing specificities. It is a 65-kDa (G148 protein G) and a 58 kDa (C40 protein G) cell surface protein that has found application in purifying antibodies through its binding to the Fc region. The native molecule also binds albumin, however, because serum albumin is a major contaminant of antibody sources, the albumin binding site has been removed from this recombinant form of Protein G.

Protein L Recombinant Protein
96-656 2 mg
EUR 405.6
Description: Protein L was isolated from the surface of bacterial species Peptostreptococcus magnus and was found to bind Ig(IgG,IgM,IgA,IgE and IgD) through L chain interaction, from which the name was suggested. Despite this wide-ranging binding capability with respect to Ig classes, Protein L is not a universal immunoglobilin-binding protein. Binding of Protein L to immunoglobulins is restricted to those containing kappa light chains (i.e., k chain of the VL domain). In humans and mice, kappa (k) light chains predominate. The remaining immunoglobulins have lambda (l) light chains. The recombinant protein contains four immunoglobulin (Ig) binding domains (Bdomains) of the native protein. Besides antibody, protein L is also suitable for binding of a wide range of antibody fragments such as Fabs, single-chain variable fragments (scFv), and domain antibodies (Dabs).

Human Brain Protein 44 Like Protein (BRP44L) Protein
20-abx167822
  • EUR 861.60
  • EUR 343.20
  • EUR 2648.40
  • EUR 1011.60
  • EUR 610.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human FK506 Binding Protein Like Protein (FKBPL) Protein
20-abx165927
  • EUR 844.80
  • EUR 343.20
  • EUR 2581.20
  • EUR 994.80
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Microtubule Associated Protein Tau / Tau Protein (MAPT) Protein
20-abx263440
  • EUR 276.00
  • EUR 1930.80
  • EUR 393.60
  • 1 µg
  • 50 ug
  • 5 ug

Microtubule Associated Protein Tau / Tau Protein (MAPT) Protein
20-abx262449
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Microtubule Associated Protein Tau / Tau Protein (MAPT) Protein
20-abx262455
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Microtubule Associated Protein Tau / Tau Protein (MAPT) Protein
20-abx262840
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Mouse FK506 Binding Protein Like Protein (FKBPL) Protein
20-abx650795
  • EUR 861.60
  • EUR 343.20
  • EUR 2698.80
  • EUR 1028.40
  • EUR 610.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Myelin Proteolipid Protein Like Protein (PLPL) Protein
20-abx654425
  • EUR 693.60
  • EUR 309.60
  • EUR 2064.00
  • EUR 828.00
  • EUR 510.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Transmembrane Protein 2 Like Protein (TMEM2L) Protein
20-abx655334
  • EUR 693.60
  • EUR 309.60
  • EUR 2064.00
  • EUR 828.00
  • EUR 510.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Recombinant Protein Export Protein SecB
7-06340 5µg Ask for price

Recombinant Protein Export Protein SecB
7-06341 25µg Ask for price

Recombinant Protein Export Protein SecB
7-06342 1mg Ask for price

Myelin P2 protein Recombinant Protein
91-218 0.05 mg
EUR 821.4
Description: Myelin P2 Protein (PMP2) is a cytoplasmic protein which belongs to the Fatty-acid binding protein (FABP) family of calycin superfamily. PMP2 is a small, basic, and cytoplasmic lipid binding protein of peripheral myelin. PMP2 is found in peripheral nerve myelin and spinal cord myelin, the oligodendrocytes and Schwann cells, respectively. PMP2 may be involved in lipid transport protein in Schwann cells. It may decrease the inhibitory effect of T suppressors in the culture of immune lymph node cells.

PDGF-Associated Protein Recombinant Protein
91-278 0.05 mg
EUR 852.9
Description: Human PAP, also known as 28 kDa heat- and acid-stable phosphoprotein, PDGF-associated protein, PDGFA-associated protein 1, PDAP1, HASPP28, is a protein which belongs to the PDAP1 family. The encoded protein in rodents has been shown to bind PDGFA with a low affinity. PDGF-Associated Protein (PAP) is a phosphoprotein that may enhance PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB. PDAP1 expression is induced by TNF-alpha, and cells overexpressing PDAP1 show significantly less apoptosis on exposure to TNF-alpha.

Myelin Protein P0 Recombinant Protein
91-643 0.05 mg
EUR 821.4
Description: Myelin Protein P0 (MPZ) is a single-pass type I membrane glycoprotein which belongs to the myelin P0 protein family. MPZ contains one Ig-like V-type (immunoglobulin-like) domain, absent in the central nervous system. MPZ is a major component of the myelin sheath in peripheral nerves. It is postulated that MPZ is a structural element in the formation and stabilisation of peripheral nerve myelin, holding its characteristic coil structure together by the interaction of its positively-charged domain with acidic lipids in the cytoplasmic face of the opposed bilayer, and by interaction between hydrophobic globular of adjacent extracellular domains. Defects in MPZ associated with Charcot-Marie-Tooth disease and Dejerine-Sottas disease.

Brevican Core Protein Recombinant Protein
91-772 0.05 mg
EUR 651.3
Description: Brevican Core Protein (BCAN) is a secreted protein that belongs to the aggrecan/versican proteoglycan family. BCAN contains one C-type lectin domain, one EGF-like domain, one Ig-like V-type domain, one Sushi (CCP/SCR) domain and two Link domains. BCAN may play a role in the terminally differentiating and the adult nervous system during postnatal development. BCAN could stabilize interactions between hyaluronan (HA) and brain proteoglycans.

VCP-like protein Recombinant Protein
91-847 0.05 mg
EUR 852.9
Description: Probable serine carboxypeptidase CPVL, also known as Carboxypeptidase, vitellogenic-like, Vitellogenic carboxypeptidase-like protein, is a member of the peptidase S10 family. It is expressed in macrophages but not in other leukocytes. And specifically, it is abundantly expressed in heart and kidney, also expressed in spleen, leukocytes, and placenta. This enzyme may be involved in the digestion of phagocytosed particles in the lysosome, and also participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.

Autophagy protein 3 Recombinant Protein
91-995 0.05 mg
EUR 374.1
Description: Ubiquitin-Like-Conjugating Enzyme ATG3 (ATG3) is widely expressed and has highly levels in heart, skeletal muscle, kidney, liver and placenta. ATG3 as a E2-like enzyme, involves in autophagy and mitochondrial homeostasis. ATG3 catalyzes the conjugation of ATG8-like proteins to PE which is essential for autophagy. As an autocatalytic E2-like enzyme, ATG3 also can catalyzes the conjugation of ATG12 to itself which palys a role in mitochondrial homeostasis but not in autophagy.

Autophagy protein 10 Recombinant Protein
91-998 0.05 mg
EUR 852.9
Description: Ubiquitin-Like-Conjugating Enzyme ATG10 (ATG10) is a ubiquitous 28kDa member of the ATG10 family protein. ATG10 acts as an E2-like enzyme, catalyzes the transfer of ATG12 to ATG5 during in the initial stages of autophagesome formation. The heterodimer of ATG5 and ATG12 subsequntly associates non-covalently with an ATG16 multimer to generate an antophagosome. ATG10 plays a role in the conjugation of ATG12 to ATG5 by interaction with MAP1LC3A. In addition, ATG10 can diretly interact with ATG5 or ATG7.

Toll-Interacting Protein Recombinant Protein
92-023 0.05 mg
EUR 821.4
Description: Toll-Interacting Protein (TOLLIP) is a member of the tollip family. TOLLIP localizes to the cytoplasm. It contains one C2 domain and one CUE domain. TOLLIP is an inhibitory adaptor protein for Toll-like receptors (TLR). The Toll-like receptors pathway is a part of the immune system that recognize structurally conserved molecular patterns of microbial pathogens, resulting in an inflammatory immune response. TOLLIP constitutes a complex with Tom1 to regulate endosomal transferring of ubiquitinated proteins. TOLLIP can negative regulate Toll-like receptors signaling, which may limit the production of proinflammatory mediators during the process of inflammation and infection.

Autophagy protein 4C Recombinant Protein
92-044 0.05 mg
EUR 852.9
Description: Cysteine Protease ATG4C (ATG4C) belongs to the peptidase C54 family. It is required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form which is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. ATG4C is a cytoplasmic protein and high expressed in skeletal muscle, liver, testis and heart. ATG4C can be inhibited by N-ethylmaleimide.

Galectin-Related Protein Recombinant Protein
92-049 0.05 mg
EUR 651.3
Description: Galectin-Related Protein (LGALSL) is a 172 amino acid protein that contains one Galectin domain. LGALSL does not appear to bind carbohydrates or lactose as the critical residues required for binding are not conserved. LGALSL may play a significant role in stimulating smooth muscle growth in developing alveolar wall vessels and the development of pulmonary capillaries.

Valosin-Containing Protein Recombinant Protein
92-101 0.05 mg
EUR 852.9
Description: Valosin-Containing Protein (VCP) is a nuclear protein that belongs to the AAA ATPase family. VCP is a putative ATP-binding protein involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. It is necessary for the fragmentation of Golgi stacks during mitosis and their reassembly after mitosis. VCP has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. VCP participates in the formation of the transitional endoplasmic reticulum (tER) and regulates E3 ubiquitin-protein ligase activity of RNF19A.

Cytoplasmic Protein NCK1 Recombinant Protein
92-102 0.05 mg
EUR 588.3
Description: Cytoplasmic Protein NCK1 (NCK1) is a cytoplasmic protein that contains one SH2 domain and three SH3 domains. NCK1 is a member of the adapter family, which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. NCK1 maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. NCK1 plays a role in the DNA damage response, but not in the detection of the damage by ATM/ATR. It is also involved in transducing signals from receptor tyrosine kinases to downstream signal recipients, such as ELK1-dependent transcriptional activation in response to activated Ras signaling.

Autophagy protein 4A Recombinant Protein
92-103 0.05 mg
EUR 852.9
Description: Cysteine Protease ATG4A (ATG4A) is a cytoplasmic protein that belongs to the peptidase C54 family. ATG4A is widely expressed in many tissues at a low level, but the highest expression is observed in skeletal muscle and brain. ATG4A is a cysteine protease required for autophagy; it cleaves the C-terminal part of MAP1LC3, GABARAPL2 or GABARAP. ATG4A is inhibited by N-ethylmaleimide. It is suggested that ATG4A has a significant role in suppressing various cancers.

Autophagy protein 5 Recombinant Protein
92-187 0.05 mg
EUR 651.3
Description: ATG5 is an E2 ubiquitin ligase which is necessary for autophagy. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity, dramatically highly expressed in apoptotic cells. It is activated by ATG7, conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate complex detaches from the membrane immediately before or after autophagosome formation is completed. ATG5 plays an important role in the apoptotic process, possibly within the modified cytoskeleton.

Centromere Protein B (CENPB) Protein
abx160005-200ug 200 ug
EUR 1513.2

Yellow Fever Envelope Protein Protein
abx160018-100ug 100 ug
EUR 661.2

Mouse Protein Z (PROZ) Protein
20-abx167987
  • EUR 861.60
  • EUR 343.20
  • EUR 2648.40
  • EUR 1011.60
  • EUR 610.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Kell Protein (KEL) Protein
20-abx168735
  • EUR 794.40
  • EUR 326.40
  • EUR 2448.00
  • EUR 944.40
  • EUR 577.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Kell Protein (KEL) Protein
20-abx168736
  • EUR 777.60
  • EUR 326.40
  • EUR 2397.60
  • EUR 927.60
  • EUR 560.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Rat Kell Protein (KEL) Protein
20-abx168737
  • EUR 794.40
  • EUR 326.40
  • EUR 2448.00
  • EUR 944.40
  • EUR 577.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Translocator Protein (TSPO) Protein
20-abx165906
  • EUR 811.20
  • EUR 326.40
  • EUR 2481.60
  • EUR 961.20
  • EUR 577.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Epididymis Protein 4 (HE4) Protein
abx061477-50pmol 50 pmol
EUR 1412.4

Epididymis Protein 4 (HE4) Protein
abx061478-50pmol 50 pmol
EUR 1412.4

Escherichia coli Protein (ECP) Protein
20-abx066464
  • EUR 693.60
  • EUR 309.60
  • EUR 2064.00
  • EUR 828.00
  • EUR 510.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Prion Protein (PRNP) Protein
20-abx068666
  • EUR 861.60
  • EUR 343.20
  • EUR 2665.20
  • EUR 1028.40
  • EUR 610.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Prion Protein (PRNP) Protein
20-abx068667
  • EUR 828.00
  • EUR 343.20
  • EUR 2532.00
  • EUR 978.00
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Protein C (PROC) Protein
20-abx068731
  • EUR 910.80
  • EUR 360.00
  • EUR 2865.60
  • EUR 1095.60
  • EUR 644.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Protein C (PROC) Protein
20-abx068732
  • EUR 878.40
  • EUR 343.20
  • EUR 2715.60
  • EUR 1045.20
  • EUR 627.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Rat Protein C (PROC) Protein
20-abx068733
  • EUR 895.20
  • EUR 360.00
  • EUR 2815.20
  • EUR 1078.80
  • EUR 644.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Protein S (PROS) Protein
20-abx068765
  • EUR 594.00
  • EUR 292.80
  • EUR 1696.80
  • EUR 693.60
  • EUR 427.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Protein S (PROS) Protein
20-abx068766
  • EUR 594.00
  • EUR 292.80
  • EUR 1696.80
  • EUR 693.60
  • EUR 427.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Rat Protein S (PROS) Protein
20-abx068767
  • EUR 777.60
  • EUR 326.40
  • EUR 2331.60
  • EUR 910.80
  • EUR 560.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Rat Protein S (PROS) Protein
20-abx068769
  • EUR 777.60
  • EUR 326.40
  • EUR 2331.60
  • EUR 910.80
  • EUR 560.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

HSPB Associated Protein 1 Protein
20-abx263199
  • EUR 276.00
  • EUR 1779.60
  • EUR 393.60
  • 1 µg
  • 50 ug
  • 5 ug

TNFAIP3 Interacting Protein 1 Protein
20-abx263201
  • EUR 276.00
  • EUR 1779.60
  • EUR 393.60
  • 1 µg
  • 50 ug
  • 5 ug

Chromatin Modifying Protein 4A Protein
20-abx263203
  • EUR 276.00
  • EUR 1779.60
  • EUR 393.60
  • 1 µg
  • 50 ug
  • 5 ug

PHD Finger Protein 13 Protein
20-abx263208
  • EUR 276.00
  • EUR 1779.60
  • EUR 393.60
  • 1 µg
  • 50 ug
  • 5 ug

Vacuolar Protein Sorting 29 Protein
20-abx263221
  • EUR 276.00
  • EUR 1779.60
  • EUR 393.60
  • 1 µg
  • 50 ug
  • 5 ug

BCL2-Related Protein A1 Protein
20-abx263280
  • EUR 1930.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 10 ug
  • 2 µg

Growth Associated Protein 43 Protein
20-abx263285
  • EUR 1930.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 10 ug
  • 2 µg

Vacuolar Protein Sorting 26A Protein
20-abx263296
  • EUR 1930.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 10 ug
  • 2 µg

Dickkopf-Related Protein 2 Protein
20-abx263304
  • EUR 1930.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 10 ug
  • 2 µg

Chromatin Modifying Protein 1A Protein
20-abx263326
  • EUR 1930.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 10 ug
  • 2 µg

Major Prion Protein (PRNP) Protein
20-abx263341
  • EUR 1930.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 10 ug
  • 2 µg

PHD Finger Protein 5A Protein
20-abx263362
  • EUR 1930.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 10 ug
  • 2 µg

B9 Protein Domain 2 Protein
20-abx263430
  • EUR 1930.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 10 ug
  • 2 µg

Calcium Binding Protein 7 Protein
20-abx263441
  • EUR 276.00
  • EUR 1930.80
  • EUR 393.60
  • 1 µg
  • 50 ug
  • 5 ug

Jun Dimerization Protein 2 Protein
20-abx263462
  • EUR 276.00
  • EUR 1946.40
  • EUR 393.60
  • 1 µg
  • 50 ug
  • 5 ug

Heat Shock Protein 20 Protein
20-abx263475
  • EUR 2047.20
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 10 ug
  • 2 µg

Lipopolysaccharide Binding Protein (LBP) Protein
20-abx263569
  • EUR 994.80
  • EUR 493.20
  • EUR 644.40
  • 10 ug
  • 2 µg
  • 5 ug

Lipopolysaccharide Binding Protein (LBP) Protein
20-abx263570
  • EUR 994.80
  • EUR 493.20
  • EUR 644.40
  • 10 ug
  • 2 µg
  • 5 ug

Dickkopf-Related Protein 1 Protein
20-abx263580
  • EUR 895.20
  • EUR 460.80
  • EUR 627.60
  • 10 ug
  • 2 µg
  • 5 ug

Protein A / G / L Protein
20-abx260039
  • EUR 2064.00
  • EUR 577.20
  • EUR 343.20
  • 100 mg
  • 10 mg
  • 1 mg

Staphylococcal Protein-A Cys Protein
20-abx260059
  • EUR 560.40
  • EUR 260.40
  • 100 mg
  • 10 mg

Staphylococcal Protein-A Cys Protein
abx260059-1gr 1 gr
EUR 2364

Staphylococcal Protein-A Cys Protein
20-abx260060
  • EUR 560.40
  • EUR 260.40
  • 100 mg
  • 10 mg

Staphylococcal Protein-A Cys Protein
abx260060-1gr 1 gr
EUR 2364

Surfactant Protein A1 (SFTPA1) Protein
20-abx260062
  • EUR 560.40
  • EUR 260.40
  • 100 mg
  • 10 mg

Surfactant Protein A1 (SFTPA1) Protein
abx260062-1gr 1 gr
EUR 2364

Surfactant Protein A1 (SFTPA1) Protein
20-abx260077
  • EUR 710.40
  • EUR 260.40
  • 100 mg
  • 10 mg

Surfactant Protein A1 (SFTPA1) Protein
abx260077-1gr 1 gr
EUR 2214

Soy Bean P34 Protein Protein
20-abx260180
  • EUR 1062.00
  • EUR 410.40
  • EUR 1930.80
  • 0.5 mg
  • 100 ug
  • 1 mg

Bone Morphogenetic protein-7 Protein
20-abx260413
  • EUR 276.00
  • EUR 2798.40
  • EUR 393.60
  • 10 ug
  • 1 mg
  • 50 ug

Heat Shock Protein 47 Protein
20-abx260420
  • EUR 276.00
  • EUR 2798.40
  • EUR 393.60
  • 10 ug
  • 1 mg
  • 50 ug

Retinoblastoma Protein 1 (RB1) Protein
20-abx260454
  • EUR 276.00
  • EUR 2798.40
  • EUR 393.60
  • 10 ug
  • 1 mg
  • 50 ug

Phosphatidylethanolamine Binding Protein 1 Protein
20-abx260464
  • EUR 276.00
  • EUR 2798.40
  • EUR 393.60
  • 10 ug
  • 1 mg
  • 50 ug

Visinin-Like Protein-1 Protein
20-abx260465
  • EUR 276.00
  • EUR 2798.40
  • EUR 393.60
  • 10 ug
  • 1 mg
  • 50 ug

Vacuolar Protein Sorting 28 Protein
20-abx260470
  • EUR 276.00
  • EUR 2798.40
  • EUR 393.60
  • 10 ug
  • 1 mg
  • 50 ug

Heat Shock Protein 27 Protein
20-abx260487
  • EUR 276.00
  • EUR 2932.80
  • EUR 393.60
  • 10 ug
  • 1 mg
  • 50 ug

Heat Shock Protein 27 Protein
20-abx260552
  • EUR 3433.20
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 25 ug
  • 5 ug

Copper Transport Protein ATOX1 Protein
20-abx260559
  • EUR 3433.20
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Macrophage-Capping Protein (CAPG) Protein
20-abx260560
  • EUR 3433.20
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 25 ug
  • 5 ug

Proliferation-associated protein 2G4 Protein
20-abx260573
  • EUR 3433.20
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 25 ug
  • 5 ug

NCK Adaptor Protein 1 Protein
20-abx260606
  • EUR 3433.20
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 25 ug
  • 5 ug

Calcium Binding Protein P22 Protein
20-abx260610
  • EUR 3433.20
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 25 ug
  • 5 ug

Myelin P2 Protein (PMP2) Protein
20-abx260645
  • EUR 3801.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 25 ug
  • 5 ug

UL16 Binding Protein 1 Protein
20-abx260710
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

EBNA1 Binding Protein 2 Protein
20-abx260778
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Heat Shock Protein 105 Protein
20-abx260801
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 25 ug
  • 5 ug

Phosphatidylinositol Transfer Protein, beta Protein
20-abx260804
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 25 ug
  • 5 ug

MAPK Scaffold Protein 1 Protein
20-abx260824
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Phosphatidylinositol Transfer Protein, alpha Protein
20-abx260827
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 25 ug
  • 5 ug

Heat-Responsive Protein 12 Protein
20-abx260828
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

BAI1-Associated Protein 2 Protein
20-abx260856
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Vacuolar Protein Sorting 25 Protein
20-abx260869
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

RAN Binding Protein 1 Protein
20-abx260876
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 25 ug
  • 5 ug

Polyglutamine Binding Protein 1 Protein
20-abx260891
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

UL16 Binding Protein 2 Protein
20-abx260906
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Homeodomain-Only Protein (HOPX) Protein
20-abx260919
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Retinoblastoma Binding Protein 4 Protein
20-abx260923
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Dickkopf-Related Protein 3 Protein
20-abx260928
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Nucleolar Protein 3 (NOL3) Protein
20-abx260930
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Tubby Like Protein 1 Protein
20-abx260934
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Chaperone Protein fimC (FIMC) Protein
20-abx260938
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 25 ug
  • 5 ug

Microfibrillar-associated Protein 4 Protein
20-abx260942
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Ring Finger Protein 181 Protein
20-abx260947
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

PHD Finger Protein 11 Protein
20-abx260969
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Hereditary Hemochromatosis Protein (HFE) Protein
20-abx261002
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug
Right here we current PAWER, the web internet device devoted solely to protein microarray evaluation. PAWER permits biologists to hold out all the required evaluation steps in a single go. PAWER offers entry to state-of-the-art computational strategies by means of the user-friendly interface, leading to publication-ready illustrations. We additionally present an R bundle for extra superior use circumstances, reminiscent of bespoke evaluation workflows.

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